Abstract. Potomac horse fever was reproduced in 15 ponies by transfusion of whole blood originally from two natural cases and subsequently from ponies infected by the transfusions. Incubation periods vaned from 9 to 15 days. Affected ponies developed varying degrees of fever, diarrhea, anorexia, depression, and leukopenia.Eleven affected ponies were killed, three died in the acute phase of the disease, and one did not show clinical signs. The most consistent post-mortem findings were fluid contents in the cecum and large colon, and areas of hyperemia (of inconstant degree and distribution) in mucosae of both small and large intestines. Multifocal areas of necrosis occurred in mucous membranes. Ehrlichial organisms were most common in the cytoplasm of epithelial cells, macrophages, and mast cells of the large colon.
Immune mediated neutropenia has been reported in human medical literature with increasing frequency over the past 30 years. A wide variety of causes are known and numerous techniques have been developed to test for the presence of antineutrophil antibody. This paper reviews literature pertaining to the pathogenesis, detection and experimental production of immune mediated neutropenia in man and animals.
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