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the most at 17 each. A total of 136 products were identified of which 36 are lyophilized powders and 100 are solutions. The routes of administration are mainly subcutaneous or intravenous infusion with three intravenous bolus, two intravitreal, and one intramuscular. The subcutaneous products are ready-to-use solutions or reconstituted lyophilized powders that do not require dilution while most intravenous products are concentrates that require dilution into saline or another intravenous fluid prior to infusion. Most are packaged in single-dose units and the exception of multi-use is Herceptin Ò and its biosimilars. The package configurations are vials, prefilled autoinjectors, or prefilled syringes. A typical antibody formulation contains an antibody, an excipient to adjust tonicity or osmolality for solutions or a lyoprotectant for lyophilized powders, a buffer, and a surfactant. The ionic tonicity-adjusting excipient is mainly sodium chloride and the non-ionic osmolality-adjusting excipients include sucrose, trehalose, mannitol, maltose, and sorbitol. The lyoprotectants are trehalose and sucrose. The pH range is 4.8-8.0 and the buffers or pHmodifying agents include histidine, citrate, succinate, acetate, phosphate, glutamate, adipic acid, aspartic acid, lactic acid, tromethamine, and 2-(N-morpholino)-ethanesulfonic acid. The surfactants include mostly polysorbate 20 or polysorbate 80, with four containing poloxamer 188, and one that does not contain a surfactant but contains PEG 3350. One product does not contain a buffer, and 12 do not contain a surfactant. The viscosity-lowering excipients are sodium chloride and the amino acids arginine, glycine, proline, and lysine. Arginine may also function to adjust ionic strength and minimize aggregation. Human serum albumin is used in 2 products for intravenous infusion. Other excipients include methionine as an anti-oxidant, and EDTA or DTPA as chelating agents. The maximum volume of subcutaneous injection is 15 mL administered over 3-5 minutes, but the typically volume is 0.5-2 mL. Five fixed-dose combinations have recently been approved and four contain hyaluronidase to assist the large volume subcutaneous injection of up to 15 mL, while one is a fixed-dose combination for intravenous with three antibodies. Prefilled autoinjectors and syringes are becoming more common and many come affixed with a needle of 27-gauge or 29-gauge, while a few have a 26-gauge or a 30-gauge needle. Recent advancements include hyaluronidase to assist the large subcutaneous injection volume of 5-15 mL, fixed-dose combinations, buffer-free formulation, and smaller subcutaneous injection volume (0.1 mL).

Electroosmotlc mobility was determined as a function of pH at constant Ionic strength by using a neutral marker. It was observed that the electroosmotlc mobility was dependent on the preconditioning of the fused silica column. The electroosmotlc mobility values that were obtained from a column previously exposed to acidic conditions for varying periods of time were consistently lower than the values from columns previously exposed to alkaline conditions, particularly in the pH 4-6 region. The equilibration of the surface charge on the fused silica surface appears to be a relatively slow phenomenon. Since the peak area In capillary zone electrophoresis varies Inversely with the solute mobility, attention should be paid to capillary preconditioning, particularly In the pH 4-6 range.

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Variation in interference relationships have been shown for a number of crop-weed associations and may have an important effect on the implementation of decision support systems for weed management. Multiyear field experiments were conducted at eight locations to determine the stability of corn-foxtail interference relationships across years and locations. Two coefficients (IandA) of a rectangular hyperbola equation were estimated for each data set using nonlinear regression procedures. TheIandAcoefficients represent percent corn yield loss as foxtail density approaches zero and maximum percent corn yield loss, respectively. The coefficientIwas stable across years at two locations and varied across years at four locations. Maximum yield loss (A) varied between years at one location. Both coefficients varied among locations. Although 3 to 4 foxtail plants m−-1row was a conservative estimate of the single-year economic threshold (Tc) of foxtail density, variation inIandAresulted in a large variation inTc. Therefore, the utility of using common coefficient estimates to predict future crop yield loss from foxtail interference between years or among locations within a region is limited.