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A new high-voltage earth-abundant cathode for sodium-ion batteries, Na2Fe(SO4)2, is reported, combining high thermal stability and good moisture resistance.

The Cu(OI)-L was suitable to be employed in combination with disulfiram for tumor treatment and can also open up opportunities for targeted delivery of copper.

Summary In order to illuminate heat recirculation effect on catalytic combustion stability and further improve energy conversion efficiency in meso‐combustor, the catalytic combustion characteristics of the combustor with/without preheating channels are numerically studied at steady conditions. It is found that methane conversion rate and combustion efficiency increases by 2% to 3% and approximately 9% in the heat recirculation meso‐combustor, indicating that heat recirculation effect facilitates more complete combustion of methane and medium components. Preheating channels show positive effects on improving combustion stability in the heat recirculation meso‐combustor. On one hand, preheating channels facilitate heat recirculation effect, and heat recirculation rate exceeds 10% for all cases and reaches 31.8% with an inlet velocity of 0.5 m/s, leading to significant increment of methane‐specific enthalpy at the preheating channel outlet. On the other hand, Rh(s)/O(s) ratios of catalytic surface and catalytic surface temperature in main reaction zone are enlarged by the preheating channels, facilitating methane adsorption at catalytic surface. Specially, most of fuels are consumed in a shorter distance with higher methane conversion speed, which brings benefits to promote combustion efficiency and may be helpful to inhibit the combustion instability in heat recirculation meso‐combustors.

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Nanosuspensions (NS) can enhance the saturation solubility and dissolution velocity of poorly soluble drugs. PEG as a non-ionic surfactant plays an important role in surface modification of nanoparticles for prolonging in vivo circulation. In this study, anti-solvent precipitation method was introduced to prepare gambogenic acid nanosuspensions (GNA-NS) with PVPK30 and PEG2000 as stabilizers to settle the disadvantages of GNA. The obtained nanoparticles were spherical with a mean particle size of 183.7 nm and a zeta potential of À22.8 mV.The entrapment efficiency and drug loading of the resultant formulation were 97.3 and 29.73%. X-ray diffraction analysis confirmed the amorphous phase of GNA in NS. Fourier transform infrared indicated there may be hydrogen bond interaction between the drug and excipients. After lyophilization of GNA-NS, the freeze-dried powder displayed sufficient longterm physical stability at 4 and 25 C. In comparison to GNA solution, in vitro studies of GNA-NS showed much slower release and higher cytotoxicity in HepG2 cells. What's more, the pharmacokinetic study in rats revealed that the AUC 0-1 and t 1/2 of GNA-NS were increased 2.63-and 1.77-fold than that of the reference formulation. Taken together, in vitro/in vivo evaluations showed NS would be an effectively strategy to change the poor aqueous solubility and prolong the half-life for GNA. The GNA-NS with enhanced bioavailability and drug efficacy provided a promising delivery system for the application of GNA. KeywordsCytotoxicity, gambogenic acid, in vivo pharmacokinetics, in vitro release, nanosuspensions History

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