Expression of miR-28-3p in patients with Alzheimer's disease (AD) before and after treatment and clinical value of miR-28-3p were determined. There were three groups: 68 AD patients treated with donepezil combined with basic therapy in The People's Hospital of Shouguang collected as an AD group, 70 patients with mild cognitive impairment (MCI) as an MCI group, and 75 healthy people as a normal group. Serum miR-28-3p was detected by qRT-PCR. The Montreal cognitive assessment scale (MoCA), mini mental state examination scale (MMSE), activities of daily living scale (ADL) and homocysteine (Hcy) were adopted to assess patients before and after treatment. miR-28-3p in normal group was significantly lower than that in other two groups, and miR-28-3p in MCI group was significantly lower than that in AD group (P<0.001). miR-28-3p correlated with the course and severity of patients. miR-28-3p in AD group after treatment was significantly lower than that before treatment (P<0.001). ADL and Hcy of AD patients after treatment were significantly lower than before treatment (P<0.05), and MMSE and MoCA after treatment were significantly higher than before treatment (P<0.05). Before and after treatment, miR-28-3p was significantly positively correlated with ADL score and Hcy level, but negatively correlated with MMSE score and MoCA score. Analysis of the working characteristic curve of the patients indicated that miR-28-3p can be used for diagnosis of AD patients. Donepezil therapy may reduce miR-28-3p level to alleviate the symptoms of AD patients, and miR-28-3p level can be used as an early diagnosis and prognosis evaluation of AD patients.

No abstract

No abstract

Ti⁴⁺-diffused Zr⁴⁺/Er³⁺-codoped LiNbO₃ strip waveguide was fabricated on an X-cut LiNbO₃ substrate by thermal diffusion in sequence of Er³⁺, Zr⁴⁺ and Ti⁴⁺. Secondary ion mass spectrometry study shows that the Ti⁴⁺ ions follow a sum of two error functions in the width direction and a Gauss function in the depth direction of the waveguide. Both Er³⁺ and Zr⁴⁺ profiles follow the desired Gauss function, and entirely cover the Ti⁴⁺ profile. Optical study shows that the waveguide is TE or TM single mode at 1.5 μm wavelength, and has a loss of 0.3 (0.5) dB/cm for the TM (TE) mode. In the case of 980 nm pumping, the waveguide shows stable 1547 nm signal output under high-power pumping without optical damage observed, and a net gain of 1.1 dB/cm is obtained for the available pump power of 120 mW.

Three metrics used in error measuring are introduced to measure the differences between the derivatives of typical signal pulses and the derivatives of Gaussian pulse, which is used as the standard ultrawideband (UWB) signals. Derivatives of two kinds of typical initial pulses compared to the standard UWB signal in the same order is evaluated under three reference metrics, when the initial pulses of them have the same pulse width. The results show that, the first metric δ1 changes linearly with the FWHM of the initial pulses TFWHM, while the second one δ2 presents a proportional relation to the square root of TFWHM, and the third one δmax does not change with TFWHM. In addition, the difference between the derivatives of hyperbolic secant pulse and the standard UWB signals are smaller compared to the derivatives of super-Gaussian pulse in the same condition.

No abstract

No abstract

No abstract