Expression of miR‑28‑3p in patients with Alzheimer's disease before and after treatment and its clinical value

Zhao, Xiaohua; Wang, Shan; Sun, Wenbao

doi:10.3892/etm.2020.8920

Cited by 12 publications

(10 citation statements)

References 48 publications

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“…This suggests that miR-339 may contribute to memory difficulty reported by older athletes with recurrent concussions. Levels of miR-28-3p have demonstrated clinical potential as a biomarker for Alzheimer’s disease [ 37 ], decreasing in expression with increasing severity of cognitive impairment. Here, we show that salivary levels of miR-28-3p were reduced in former professional football athletes and demonstrated a direct relationship with the number of prior concussions in younger individuals.…”

Section: Discussionmentioning

confidence: 99%

Saliva microRNA Biomarkers of Cumulative Concussion

Hicks

Olympia

Onks

et al. 2020

IJMS

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Recurrent concussions increase risk for persistent post-concussion symptoms, and may lead to chronic neurocognitive deficits. Little is known about the molecular pathways that contribute to persistent concussion symptoms. We hypothesized that salivary measurement of microribonucleic acids (miRNAs), a class of epitranscriptional molecules implicated in concussion pathophysiology, would provide insights about the molecular cascade resulting from recurrent concussions. This hypothesis was tested in a case-control study involving 13 former professional football athletes with a history of recurrent concussion, and 18 age/sex-matched peers. Molecules of interest were further validated in a cross-sectional study of 310 younger individuals with a history of no concussion (n = 230), a single concussion (n = 56), or recurrent concussions (n = 24). There was no difference in neurocognitive performance between the former professional athletes and their peers, or among younger individuals with varying concussion exposures. However, younger individuals without prior concussion outperformed peers with prior concussion on three balance assessments. Twenty salivary miRNAs differed (adj. p < 0.05) between former professional athletes and their peers. Two of these (miR-28-3p and miR-339-3p) demonstrated relationships (p < 0.05) with the number of prior concussions reported by younger individuals. miR-28-3p and miR-339-5p may play a role in the pathophysiologic mechanism involved in cumulative concussion effects.

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Section: Discussionmentioning

confidence: 99%

Saliva microRNA Biomarkers of Cumulative Concussion

Hicks

Olympia

Onks

et al. 2020

IJMS

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“…MiRNA 487b-3p is involved in colon cancer, osteosarcoma, and anaphylactic reactions [38,39]. MiRNA 28-3p is involved in Alzheimer's, nasopharyngeal cancer, gastric cancer, thyroid cancer, and esophageal squamous cell carcinoma [40,41,42]. MiRNA 532-5p is involved in breast cancer, glioma, gastric cancer, ovarian cancer, renal carcinoma, and ischemic stroke [27,43,44,45,46,47].…”

Section: Discussionmentioning

confidence: 99%

Potential microRNA biomarker panel for predicting evolution of pancreatitis to pancreatic ductal adenocarcinoma

Nuthakki¹,

Utti²,

McCalla³

2023

Preprint

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Purpose Pancreatitis is one of the most important risk factors for pancreatic ductal adenocarcinoma (PDAC). PDAC is a silent, aggressive malignancy that has less than 5% survival rate at 5 years. Detection at early stage and resection of PDAC significantly improves survival. A differentially expressed microRNA panel was sought that could predict the risk of progression to PDAC from pancreatitis. Methods Differentially expressed microRNA (DEM) in serum that were common between pancreatitis and PDAC were extracted from two microarray GSE datasets containing pancreatitis, PDAC, and control samples. Eight groups of DEM were derived from multiple bioinformatics methods such as differential expression, miRNA interaction networks, target gene prediction tools, functional enrichment analysis, and machine learning models. The functional enrichment pathway of these groups were identified. Results These groups were trained on the original datasets and were used to predict pancreatic cancer in a validation set consisting of six other GSE datasets containing pancreatic cancer and controls. The miRNA panel with the highest precision and recall was the group derived from the target hub genes with the highest interaction (hsa-miR-28-3p, 320b, 320c, 320d, 532-5p, and 423-5p, with a mean F1 of 0.968, mean recall of 0.99, mean precision of 0.947, and mean AUC of 0.995). Conclusion These results provide a potential biomarker to identify and follow individuals at high risk for pancreatic cancer after pancreatitis.

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“…Besides, Liu et al revealed that miR-211 exerted protective effects on OGD/R-challenged PC12 cells via reducing cell apoptotic rate [ 49 ]. MiR-28-3p is differently regulated in human diseases and deeply involved in the regulation of cellular functions [ 50 ]. In addition, Fan et al disclosed that miR-28-3p expression was negatively related to IL-1β level in colorectal cancer [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis

Wang¹,

Wang²

2021

Bioengineered

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Cerebral ischemia/reperfusion (CI/R) injury results in serious brain tissue damage, thereby leading to long-term disability and mortality. It has been reported that dexmedetomidine (DEX) exerted neuroprotective effects in CI/R injury. Herein, we intended to investigate whether and how circular RNA (circRNA) cerebellar degeneration-related protein 1 antisense RNA (circ-CDR1as) was involved in the DEX-mediated protection on hippocampal neurons. In our work, the mouse hippocampal neuronal cells (HT-22) were used to construct a hypoxia/reperfusion (H/R) model for CI/R injury. Cell proliferation and apoptosis were evaluated by CCK-8 and flow cytometry. Gene expressions were detected by RT-qPCR. Levels of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) were measured by ELISA. The association between miR-28-3p and circ-CDR1as or TRAF3 was verified by dual-luciferase assay. The results indicated that DEX alleviated HT-22 cell dysfunction induced by H/R treatment. In addition, circ-CDR1as was downregulated after DEX treatment and reversed the effects of DEX on the proliferation, apoptosis, and inflammatory responses of H/R-treated HT-22 cells. Circ-CDR1as positively regulated TRAF3 expression via interaction with miR-28-3p in HT-22 cells. Circ-CDR1as aggravated H/R-treated HT-22 cell dysfunction through targeting miR-28-3p. Furthermore, TRAF3 inhibition partly abolished the effect of circ-CDR1as overexpression on cellular activities of H/R-treated HT-22 cells. To sum up, our findings, for the first time, demonstrated that DEX exerted neuroprotective effects on hippocampal neurons against H/R treatment via the circ-CDR1as/miR-28-3p/TRAF3 regulatory network, providing novel therapeutic targets for DEX administration in CI/R treatment.

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Expression of miR‑28‑3p in patients with Alzheimer's disease before and after treatment and its clinical value

Cited by 12 publications

References 48 publications

Saliva microRNA Biomarkers of Cumulative Concussion

Saliva microRNA Biomarkers of Cumulative Concussion

Potential microRNA biomarker panel for predicting evolution of pancreatitis to pancreatic ductal adenocarcinoma

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