Recently,
the development of nanozymes with high catalytic performance
is gaining more and more attention due to the ever-growing demands
for their practical applications. The elaborate design of its morphology
has demonstrated to be an effective approach to improve the performance
of these nanozymes. Herein, a hybrid of iron disulfide nanoparticles
(FeS2 NPs) encapsulated by two-dimensional (2D) carbon
nanosheets (NSs), denoted as FeS2@C NSs, demonstrates both
superior peroxidase-like activity and excellent stability. The incorporation
of 2D carbon sheets endows the proposed FeS2@C nanozymes
with high specific surface area, providing abundant active sites to
facilitate the contact with substrates. Moreover, the embedded FeS2 NPs are kept from aggregation due to the encapsulation and
confinement of 2D carbon sheets, avoiding the conventional failure
of single-component nanozymes. Based on glucose oxidase (GOx) and
the elaborately designed FeS2@C nanozymes, a colorimetric
method for glucose detection is then developed with excellent simplicity
and sensitivity. The detection limit of the sensing platform is as
low as 0.19 μM for a glucose assay. More notably, this method
can be successfully employed for the glucose assay in some real samples,
indicating the great potential of this FeS2@C NS-based
nanozymes in the fields of biotechnology and clinical diagnostics.
In the past few years, the development of novel nanozymes with excellent performance has attracted an increasing attention on biosensing. However, most of those nanozymes are found to possess peroxidase...
The partial positive charge of amide protons is used to promote macrocyclization and form crown-ether analogs. Their deprotonation generates very selective pH-switchable alkaline earth ion receptors only in the presence of an appropriate substrate.
N,N'-Disubstituted formamidines, and amidines in general, have very rich configurational, conformational, and tautomeric diversities. As part of an effort to incorporate alkoxyamine-derived formamidine units into foldamers, the first evidence for the isolation of the up-to-now unknown E isomer, the conditions for its exclusive formation, its stability and self-assembly properties, and its configurational isomerization to its much more common Z counterpart are reported. Considering the distinctly different H-bonding patterns displayed by both E and Z isomers, such configurational control may find applications in self-assembly, molecular recognition, and biomimetic systems.
The formamidoxime configurational Z isomer coupled with the pyridylbiscarboxamide conformational codon were used to fold planar, curved structures. When embedded into macrocycles, this folded motif promotes dimerization through π-π stacking and hydrogen-bonding and the formation of tubules akin to molecular channels in the solid state.
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