Enantioconvergent catalysis has the potential to convert
different
isomers of a starting material to a single highly enantioenriched
product. Here we report a novel enantioselective double convergent
1,3-rearrangement/hydrogenation of allylic alcohols using an Ir-N,P
catalyst. A variety of allylic alcohols, each consisting of a 1:1:1:1
mixture of four isomers, were converted to the corresponding tertiary
alcohols with two contiguous stereogenic centers, in up to 99% ee and 99:1 d.r. DFT calculations, and
control experiments suggest that the 1,3-rearrangement is the crucial
stereodetermining element of the reaction.
A radical cyclization and ring-opening of oxime esters with diselenides was developed. Both Ni(0) and Fe(II) catalysts could be employed for the selenylation of olefin-containing and cyclic oxime ester derivatives....
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