The cobalt-catalyzed cross-dehydrogenative coupling of (benz)oxazoles and ethers is described. Access to some important bioactive heteroaryl ether derivatives was achieved using CoCO as an inexpensive catalyst at levels as low as 1.0 mol %. Investigation of the mechanism indicates a catalytic cycle involving a radical process.

A novel four-component strategy for selective synthesis of fused azepino[5,4,3-cd]indoles and pyrazolo [3,4-b]pyridines has been established. The bond-forming efficiency, accessibility of starting materials and substrate scope provide an invaluble access to tetra-, and bis-heterocyclic scaffolds.

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finger (refluxing EtgO) affords pure [®Li]ethyllithiuin in 20-80% (typically 50-60%) isolated yields. For optimal results, the [®Li]ethyllithimn should be freshly sublimed before each use:

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