Background and Objectives: Obese Indonesians, including Balinese, are at higher risk of comorbidities like, CVD, diabetes, non-alcoholic fatty liver disease. Urban Balinese are changing their diet from traditional to fast foods and the like that are high in saturated fats. Nutritional modification, such as increasing n-3 PUFA content in the diet, may aid in managing body fat accumulation-related diseases. This study investigated the effects of supplementation of n-6:n-3 PUFA with ratio of 2:1 on body fat reduction in young obese Balinese women. Methods and Study Design: Sixty-six young obese Balinese women, aged 18-25, were randomly assigned equally into Intervention and Control groups, supplemented with 2100 mg:1100 mg and 240 mg:100 mg of n-6:n-3 PUFAs, respectively. Data were collected at baseline, 6, and 12 weeks of intervention. BMI, waist circumference (WC), waist-to-height ratio (WHtR), conicity index, triglyceride concentrations, and Lipid Accumulation Product (LAP) were measured. Participants were advised to maintain <1500-Kcal daily energy intake and participate in a guided low-impact aerobics once a week. Results: After 12-weeks supplementation, all body fat indices (BMI, WC, WHtR, conicity index, and LAP), decreased significantly weather were unadjusted or adjusted by the reduced of energy intake in the Intervention group. Otherwise, in the Control group only some of WC indices (WC, WHtR, and conicity index) decreased stasticically. BMI and WC of the Intervention group decreased significantly more than the Control group. Conclusion: Twelve-week intervention with high-dose of low n-6:n-3 PUFAs ratio and restriction energy intake, reduced body fatness selectively in young obese Balinese women.

Objectives: In addition to the rise in obesity prevalence globally, morbidity due to nonalcoholic fatty liver disease is increasing. Primary modalities for preventing and managing this problem include dietary modification and improved physical activities. A daily diet with a low n-6:n-3 polyunsaturated fatty acid (PUFA) ratio is suspected to contribute to ameliorating liver steatosis (LS). The present study was conducted to elucidate the effects of an n-6:n-3 PUFA ratio of 2:1 in alleviating LS.Methods: Twenty-four young obese women with LS were recruited from Denpasar, Bali, Indonesia. They were randomly allocated to an intervention or control group. Both groups were given linoleic acid:α-linolenic acid at ratios of 2035:970 and 240:100 g, respectively, for 12 weeks. Baseline and end-line data were obtained. All patients were advised to maintain their daily energy intake no more than 1500 kcal and to perform structured physical exercises once a week. Results:The intervention significantly decreased the body fat (body mass index, p=0.040; triglyceride, p=0.008) and serum tumor necrosis factor-α (TNF-α) levels (p=0.002) and increased serum interleukin-10 (IL-10) levels (p=0.004). The severity of LS was reduced through the intervention (odds ratio=0.064; 95% confidence interval=0.013-0.310; p=0.001).Conclusion: An increased intake of 2:1 n-6:n-3 PUFA ratio alleviated LS, decreased body fat composition and serum TNF-α levels, and increased serum IL-10 levels.

Introduction: Nasopharyngeal carcinoma is the most common malignant tumor in the ENT-HNS were the highest of all malignant tumors of the head and neck. Malnutrition and cachexia is a common problem in cancer patients and impact on quality of life and survival. Anemia is a major problem in patients with nasopharyngeal cancer receiving chemotherapy or radiotherapy. Objective: Determine the relationship of nasopharyngeal carcinoma stage with anemia and nutritional status. Material and methods: This study used cross sectional analytic method. Data were obtained from medical records of patients with nasopharyngeal carcinoma who were treated in province hospital West Nusa Tenggara period January 2018 to December 2018. Data collected include the identity, diagnosis, hemoglobin value, weight and height. Having analyzed the data collected are looking for is there a relationship between stage nasopharyngeal carcinoma with anemia and nutritional status. Results: In this study, Shapiro-Wilk normality test. Anova is then performed to analyze the relationship stage nasopharyngeal carcinoma with anemia status obtained 95% CI, p value 0.847, there is no difference between stage nasopharyngeal carcinoma with anemia. Kruskal Wallis test to analyze the relationship with BMI (body mass index) with stage nasopharyngeal carcinoma obtained 95% CI, p value 0.565. There is no difference in BMI with stage nasopharyngeal carcinoma. Conclusion: There is a tendency to lower Hb in patients with nasopharyngeal cancer further stage although there is no significant difference between each stage. The same thing was found in BMI, BMI decreased tendency in patients with advanced nasopharyngeal cancer although there was no statistically significant difference.

BACKGROUND:The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally. Early identification of liver steatosis (LS) status is critical to prevent the development of NAFLD into non-alcoholic steatohepatitis (NASH) fibrosis.AIM:This study aimed at exploring the validity of simple anthropometric and biochemical parameters to predict LS in young obese women.MATERIALS AND METHODS:This is a cross-sectional study involving 132 young obese women. We collected the data of measured waist circumference (WC), body mass index (BMI), serum triglyceride (TG), and gamma-glutamyltransferase (GGT). The lipid accumulation product (LAP) was designed from TG and WC variables. Fatty liver index (FLI) was calculated from TG, BMI, WC, and GGT variables. LS status was measured using ultrasonography assay. Statistical significance was set at p < 0.05.RESULTS:A positive correlation was found between BMI, WC, TG, GGT, LAP, FLI, and LS (p = 0.001). We found that BMI is a better predictor for LS to WC. Our multiple linear regression analysis revealed that BMI, GGT, and TG could predict 41.4% of LS. The validity (specificity, sensitivity, and odds ratio) of simple body fat parameters in predicting LS were as follows: BMI ≥ 30 kg/m2 (69.6%, 74.4%, and 6.21), WC ≥ 90 cm (67.4%, 70.0%, and 4.28), TG ≥ 100 mg/dL (70.6%, 70.0%, and 5.62) and GGT ≥ 20 μg/L (69.6%, 77.5%, and 7.87), as well as LAP ≥ 30 (82.6%, 70.0%, and 11.1), and FLI ≥ 2.5 (79.3%, 72.5%, and 10.1), significantly.CONCLUSION:Simple anthropometric and biochemical parameters (BMI, WC, and TG, GGT), are appropriately predicting LS as well as LAP, and FLI among obese Balinese young women.

Nasopharyngeal carcinoma (NPC) patients who are undergoing chemoradiotherapy, it is important to have a hematological profile examination to see hemoglobin and erythrocyte levels, the incidence of infection that has an effect on leukocyte levels and the risk of bleeding arising from a decrease in platelet levels. hematopoietic system. This study is a descriptive study using data from medical records of nasopharyngeal cancer patients at the NTB Provincial Hospital for the period January 2019 to December 2020. The data collected included patient identity, diagnosis, hemoglobin levels, erythrocyte index, leukocytes and platelets. Nasopharyngeal cancer is established through anamnesis, physical examination, histopathology and radiological investigations. Routine hematological examination is important in NPC patients to determine the presence of hematological abnormalities. Generally, the higher the NPC stage, the more complete the haematological abnormality will be. The incidence of anemia is related to the continuation of therapy and the patient's quality of life. Leukocytosis is associated with the more progressive cancer; this leukocytosis will also increase platelet cells and cancer cells themselves. Thrombocytosis can be associated with advanced stage or metastases and a poor prognosis in NPC. Leukopenia can cause a decrease in the immune system so that patients are susceptible to infections, both bacterial and viral. Thrombocytopenia can increase the risk of bleeding.