Background: The aim of this study was to identify differences in oral cancer incidence among sexes, age groups and oral sites over time in Iraqi population. Methods: Data was obtained from Iraqi cancer registry, differences and trends were assessed with the Wilcoxon matched-pairs signed-ranks test and Regression test, respectively. Results: In Iraq from 2000 to 2008, there were 1787 new cases of oral cancer registered, 1035 in men and 752 in women. Cancer at all oral sites affected men more than women. The Tongue other (ICD-02) is the most frequent site follow by lip (ICD-00). Conclusion: The decrease in the percent of oral cancer incidence in Iraq not compatible with the high percent of exposure to the risk factors, Iraqi cancer registry failed in collecting data concerning risk factor and the mortality rate.ª 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.

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Background: Central giant cell granuloma (CGCG) and peripheral giant cell granuloma(PGCG) are pathological conditions of the jaws that share the same microscopic features, but differ clinically in terms of their behavior. While the giant cell tumor (GCT) of long bones is a rare benign neoplasm, tend to affect femur and tubular bone, characterized by local aggressiveness, high recurrence rates and metastasis to the lung. Objectives: To evaluate, compare and correlate the expression of TNF-α, IL-6 and VEGF in peripheral and central giant cell granuloma of the jaw and giant cell tumor of long bones. Methods: A total of 60 retrospective formalin-fixed, paraffine-embeded specimens of giant cell lesions of the jaws and long bones, where included in this study. An immunohistochemical staining with TNF-α , IL-6 and VEGF monoclonal antibodies were performed. Results: TNF-α, IL-6 and VEGF were expressedin all lesions. The PGCG comparedto the CGCG and GCT showed significantly increased expression of TNF-α and decreased expression of VEGF by the stromal cells..GCT showed increased expression of VEGF by M NGCs and stromal cells .There is a non significant difference between CGCG and GCT regarding the expression of all three cytokines. Conclusions:The present study confirmed the usefulness TNF-α,IL-6 and VEGF in evaluating osteoclastogenesis. The results of this study proved that the biological activity of TNF-α, IL-6 and VEGF was comparable between the central giant cell granuloma and giant cell tumors, supporting the observations that these two lesions are the same entity and have the same biological behavior.

Background: Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity that exhibits certain histological variations. Verrucous carcinoma (VC) is an uncommon exophytic low-grade welldifferentiated variant of SCC. Cellular differentiation and morphology play important roles in cell functions and maintenance of structural integrity .As the cancer is a malignant process in which disorder of the cell growth and behavior occurs, such changes may differ in different tumor types and within different grades of the same tumor. Materials and Methods:Forty two formalin-fixed, paraffin-embedded tissue blocks were included in this study (30 blocks were diagnosed as OSCC and 12 blocks were diagnosed as OVC). An immunohistochemical staining was performed using anti moesin, anti CK14 and anti MMP7 monoclonal antibodies. Results: Moesinimmunoreactivity was recognized in all the studied groups with predominant cytoplasmic expression in OSCC & membranous expression in OVC. No difference was noticed between 2 studied groups &between different grades of OSCC. Cytokeratin 14 positivity was noticed in all studied groups with significant difference between OSCC&OVC (p=0.012) & there was a significant difference between the different grade of OSCC (p=0.047). MMP7 expression was observed in the all studied groups with predominant cytoplasmic pattern in OSCC & nuclear pattern in OVC. No difference was found between the 2studied groups &between the different grades of SCC. A Strong positive linear correlation between MMP7&CK14 was noticed. Conclusion: Verrucous carcinoma has a specific pattern for moesin and MMP7 that differs from OSCC, however; the difference is not significant. CK14 immunoreactivity indicated a significant difference in the degree of cellular differentiation between OSCC &OVC.