Hand blood flow was measured at rest, with local warming, and with local cooling. Three methods were simultaneously used: water plethysmography (WP), mercury-in-rubber strain gauge plethysmography (SG), and pulsed Döppler flowmetry (D). Of these, water plethysmography is the most sensitive and accurate; strain gauge plethysmography is simpler but less accurate; and pulsed Döppler flowmetry precisely measures instantaneous arterial blood flow without venous occlusion.
Pulmonary vascular pressure, blood flow, and blood volume were measured in the supine and sitting positions in eight subjects with localized lung carcinoma associated with moderate airway obstruction. Supine cardiac output, pulmonary wedge (Ppw) and artery (Ppa) pressure, and pulmonary vascular resistance (PVR) were normal. Circulatory changes in sitting position were also normal: heart rate increased 13 +/- 9% (mean +/- SD); stroke volume fell 21 +/- 15%; cardiac output fell 13 +/- 19%; and arteriovenous O2 difference increased 37 +/- 21%. Neither the difference between mean Ppa and mean Ppw nor the rise of PVR from 92 +/- 25 to 122 +/- 49 dyn.s.cm-5 in sitting position were significant. Pulmonary blood volume (PBV) as measured by a dye-bolus-injection technique fell from 517 +/- 122 ml supine to 360 +/- 43 ml sitting (P less than 0.01). This decrease is best explained by closure of alveolar vessels in the upper part of the lung and by the concomitant cessation of flow in corresponding extra-alveolar vessels, which would prevent distribution of dye in the region. Circumstantial evidence suggests the latter vessels remain open under the large expanding stresses that prevail in the upper lung.
surgical resection has a OS median of 21 months and a maximum survival of 32 months; patients treated with locoregional treatments had a maximum OS of 40 months with a median of 14 months; As for patients who received systemic treatment from the moment of diagnosis had a maximum survival of 22 months with a median of 10 months and those who did not received any treatment had a survival of 8 months. Conclusion: The majority of patients were diagnosed in intermediate and advanced stages, the best survival rates were achieved with surgical resection, followed by TACE. The OS median was 12 months and the EFS median was 9 months, mainly for early stages. A strategical plan for the early diagnosis of HCC is needed in order to obtain better survival rates in patients with HCC.
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