Percutaneous absorption has received comparatively little attention in occupational health, although this route of entry has repeatedly caused occupation-related intoxications. In practice, the evaluation of skin penetration rates is far from simple. Much evidence has been obtained from studies of chemicals used for cosmetics and topical therapeutics, but the information available on compounds encountered in occupational health is limited. The data obtained from experimental studies have confirmed that the concentration, type of vehicle, skin area, skin condition, and extent of occlusion are important factors in determining the degree of percutaneous absorption, but no general model has been developed. Also, too little is known about the basic chemical properties governing the rate of penetration. Thus, prediction is difficult and bound to be rather inaccurate. Current preventive practice follows the procedure used by ACGIH and is mainly based on a "skin" denotation in official listings of chemicals to which exposure limits have been allocated. The number of substances and groups of chemicals which have received skin denotation in 17 selected countries varies between 24 and 179 and a total of 275 are listed as a skin hazard in one or more countries; ACGIH lists 143. Thus, the denotation practice varies. As an unfortunate result of these discrepancies and the dichotomy of skin denotation, the absence of skin denotation may erroneously indicate that efforts to protect the skin are unnecessary. Thus, an evaluation of skin penetration potentials should be incorporated in occupational health practice as a supplement to the official denotations.
A computer-based data network containing information on potentially toxic chemicals released into the environment is being developed by the Joint Research Centre of the Commission of the European Communities and by research institutions in the member states as part of a program for environmental research. The information requested daily by toxicologists involved in administration, scientific research, and clinical or forensic toxicology covers different fields or disciplines. The data base, which is still in a pilot phase, collects data on environmental chemicals (about 30,000) spread over more than 100 data fields. These include identification; physical and chemical properties; analytical methods; economic data; hazard classifications for transport, handling and storage; waste disposal; environmental dispersion and transformation; toxicology: acute and chronic effects, carcinogenicity, mutagenicity, behavioral effects; occupational air standards, first-aid treatments in case of poisoning or environmental disaster. Data stored in the data bank are original literature data which have been evaluated by specialists.
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