Hepatic drug metabolizing activity in lead-poisoned rats

Scoppa, P.; Roumengous, M.; Penning, W

doi:10.1007/bf01930408

Cited by 68 publications

(21 citation statements)

References 13 publications

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“…In contrast the results of Alvares, Leigh, Cohn & Kappas (1972) and Scoppa, Roumengous & Penning (1973) (Maines & Kappas, 1976a With progressive increase in lead treatment there was an associated rise in the activity of hepatic ALA synthase in the lead-treated animals as compared to their appropriate controls (Table 2). This was highly significant (P < 0.001) in the lead-treated animals of groups 3 and 4 with respect to their appropriate controls.…”

Section: Introductionmentioning

confidence: 84%

“…Results of previous animal (Alvares et al, 1972;Scoppa et al, 1973) and human (Alvares et al, 1975; studies have demonstrated that lead inhibits the elimination of drugs metabolized by the cytochrome P-450-dependent microsomal mixed function oxidase system. It has been suggested by these authors that the decreased capacity for drug handling results from reduced availability of cytochrome P-450 due to inhibition of haem biosynthesis by lead.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested by these authors that the decreased capacity for drug handling results from reduced availability of cytochrome P-450 due to inhibition of haem biosynthesis by lead. Indirect evidence of such a mechanism has been obtained by measuring inhibition of the activity of the haem biosynthetic enzyme ALA dehydratase (Alvares et al, 1972;Scoppa et al, 1973;. It has also been suggested that lead exerts its action directly on the hepatic mixed function oxidase system (Alvares et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

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Hepatic Drug Metabolism and Haem Biosynthesis in Lead‐poisoned Rats

Goldberg

Meredith

Miller

et al. 1978

British J Pharmacology

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1 Pretreatment of rats with intraperitoneal injections of lead was shown to result in a depression of the microsomal mixed function oxidase system, as assessed by a decrease in hepatic microsomal P-450 and b5 content and by a decrease in the activity of the enzymes aniline hydroxylase and aminopyrine demethylase. Lead had a more marked effect on cytochrome P-450 than b5. 2 The activity of the rate-limiting enzyme of haem biosynthesis, c-aminolaevulinic acid synthase, was inversely correlated with the microsomal cytochrome P-450 content. 3 The activity of the haem biosynthetic enzymes 6-aminolaevulinic acid dehydratase, coproporphyrinogen oxidase and ferrochelatase were decreased by increasing lead pretreatment. 4 The activity of the haem catabolic enzyme, haem oxygenase, was increased by lead pretreatment. IntroductionIt has long been recognized that haem synthesis in man is severely affected by increased body lead burden. This inhibition of haem production is well known to result in decreased levels of circulating haemoglobin in lead-exposed individuals. The possibility of altered drug metabolism due to inhibition of synthesis of the microsomal haemoprotein cytochrome P-450 has been the subject of a number of studies both in man and animals.Recent reports (Alvares, Kapelner, Sassa & Kappas, 1975; Meredith, Campbell, Moore & Goldberg, 1977)

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hepatic Drug Metabolism and Haem Biosynthesis in Lead‐poisoned Rats

Goldberg

Meredith

Miller

et al. 1978

British J Pharmacology

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“…These structures appear in liver parenchymal cells of children (Blackman 1936, Popoff et al 1963, dogs (Zook 1972), and rats (Moore and Goyer 1974) after their appearance in the kidney. Liver weight of rats is increased probably due to edema (Scoppa et al 1973). Some hemosiderosis is seen in the spleen of rabbits (Hass et al 1964) and in the liver of dogs, and many parenchy mal cells have enlarged nuclei (Zook 1972).…”

Section: Peripheral Nervous Systemmentioning

confidence: 99%

“…The activity of the drug-metabolizing enzymes is reduced via impairment of the mixed-function oxidase system (Scoppa et al 1973) and also by reduced availability of cytochrome P-A50 (Alvares et al 1972). Lipid peroxidation by microsomal enzymes is inhibited by the same mechanism (Pani et al 1975).…”

Section: Peripheral Nervous Systemmentioning

confidence: 99%

Effects of lead on collagen synthesis and renal function in the rat

Rodolfo-Sioson

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Some Actions of Lead on the Sperm and on the Male Reproductive System

Thomas

Brogan

1983

American J Industrial Med

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There is evidence that lead t:an exert a toxk a,•tion uron 1he male reproductive ~ystem.Likewise, there is evidence 1 hal ~ome ur 1 he effects 1 hat lead exerl ~ upon other biological syslcms might also affect male rcproduct ive capadty. Difft:'rcnccs in rt:'sponse to the toxic net ions ortead can, in part, he attribmcd l<1 d ifference~ in dose. duration . nnd methou of exposure, .species, and lack of comparablt: cxperime nt ul designs. Ne vcrthclt'ss , a >permatotoxic unci gonadoloxit! effect of lead has been seen in a varicl y or ..;pedes induding man . Furthcrmor¢, leau e. wosurc hn~ hcen linked tb chromo~omal abcrrutiun~ in workers .

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Hepatic drug metabolizing activity in lead-poisoned rats

Cited by 68 publications

References 13 publications

Hepatic Drug Metabolism and Haem Biosynthesis in Lead‐poisoned Rats

Hepatic Drug Metabolism and Haem Biosynthesis in Lead‐poisoned Rats

Effects of lead on collagen synthesis and renal function in the rat

Some Actions of Lead on the Sperm and on the Male Reproductive System

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