Penetrating injuries affecting the parotid gland are relatively rare compared to injuries affecting other head and neck structures. Likewise, foreign bodies impacting the parotid gland are extremely rare. These foreign bodies can be secondary to penetrating injury or may reach the parotid gland by retrograde migration through Stensen's duct. Management of parotid gland foreign bodies is a challenging clinical situation for otolaryngologists due to the course of the facial nerve through the gland. In this article, a patient with penetrating parotid injury as a result of the explosion of a torpedo-shaped firecracker is presented. This object's injury to the parotid gland is presented for the first time in the literature. In addition, the importance of detailed physical examination was emphasized, as foreign bodies may embed under the skin in such injuries.
Lipomas are benign neoplasms of mesenchymal origin. Although they are frequently seen in other parts of the body, they are rare in the oral cavity. In the oral cavity, they most often develop from buccal mucosa. They tend to grow slowly, so they may remain asymptomatic for a long time and go unnoticed. Lipomas in the oral cavity may cause deterioration in chewing-speaking and esthetic problems over time, depending on the increase in their size. The most reliable imaging method for differential diagnosis is magnetic resonance imaging. Complete excision of the lipoma is essential for treatment. In this study, a case of an unusual oral lipoma, causing nutrition-speaking difficulties in a geriatric male patient is presented.
SUMMARY
Objectives
The aim of this study was to compare the distribution of the angiotensin-converting enzyme (ACE) I/D polymorphism between patients with laryngeal cancer (LC) and a control group and to examine the distribution of this polymorphism with clinical parameters related to LC.
Methods
We enrolled 44 LC patients and 61 healthy controls. The ACE I/D polymorphism was genotyped with the PCR-RFLP method. The distribution of ACE genotypes (II, ID, and DD) and alleles (I or D) was evaluated with Pearson’s chi-square test, and logistic regression analysis was performed for statistically significant parameters.
Results
There was no significant difference in ACE genotypes and alleles between LC patients and controls (p = 0.079 and p = 0.068, respectively). Among clinical parameters related to LC (extension of tumour, node metastasis, tumour stage and tumour location), only the presence of node metastasis was found to be significant in terms of ACE DD genotype (p = 0.137, p = 0.031, p = 0.147, p = 0.321 respectively). In the logistic regression analysis, the ACE DD genotype was increased 8.3 fold in nodal metastases.
Conclusions
The findings of the study suggest that ACE genotypes and alleles do not affect the prevalence of LC, but the DD genotype of ACE polymorphism may increase the risk of lymph node metastasis in LC patients.
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