The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps

Yasan, Hasan; Okur, Erdoğan; Tüz, Mustafa; Sivrice, Mehmet Emre; Akın, Vural; Şirin, Fevzıye Burcu; Kıran, Eltaf Doğan

doi:10.1007/s00405-022-07413-8

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…Our data show that Raftlin levels in whole nasal tissue pieces, analyzed by ELISA assay, showed no significant differences among the CRSwNP and CRSwNP + SK groups when compared to the control group. Interestingly, a recent report from Turkey revealed that nasal polyp tissue Raftlin levels in a CRSwNP group were significantly lower than those of the control group, with no significant differences between CRSwNP and CRSwNP groups regarding asthma [ 32 ]. Their data were unlike ours, suggesting that there could exist differences in the profiles of inflammatory biomarkers between CRS patients from different races.…”

Section: Discussionmentioning

confidence: 99%

“…The other pathogenetic factors for CRSwNP, such as a humid environment, air pollution, as well as ethnic genotype, are distinct in Taiwan, which might help explain the different inflammatory patterns of CRS between Asian and Western populations [ 35 , 36 ]. Only one study has examined the Raftlin in CRSwNP patients in Turkish populations [ 32 ], but no previous reports have investigated Raftlin expression in smoking and non-smoking CRSwNP for Taiwanese people. This study is necessary for understanding the effect of Raftlin-associated signaling in the pathogenesis of CRS.…”

Section: Discussionmentioning

confidence: 99%

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Expression of Major Lipid Raft Protein Raftlin in Chronic Rhinosinusitis with Nasal Polyps in Smoking and Non-Smoking Patients Correlated with Interleukin-17 and Tumor Necrosis Factor-α Levels

Lin

Tsai

et al. 2022

Biomolecules

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Raftlin, as an inflammatory biomarker, has been previously reported in chronic inflammatory diseases. This study investigates the expression of Raftlin in cigarette smokers and in chronic rhinosinusitis with nasal polyps (CRSwNP), as well as evaluating its correlation with interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α) levels. A total of 30 CRSwNP non-smoking and 16 CRSwNP + SK (smoking) patients undergoing endoscopic sinus surgery were enrolled, while 20 middle turbinate tissue pieces were examined and performed as the control group. In nasal mucosa epithelial staining, Raftlin levels were elevated in the columnar cells and were stained much more intensely in the CRSwNP and CRSwNP + SK groups. Raftlin was located more closely to the apical region of the epithelium in the CRSwNP + SK group; however, the Raftlin levels from whole nasal tissue pieces, according to ELISA data, showed that there was no significant difference between the three different study groups. A positive relationship by Pearson correlation was found between IL-17 or TNF-α levels and Raftlin levels. Taken together, these data indicate that increasing Raftlin expression in columnar cells might involve nasal epithelial remodeling in smokers with CRSwNP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Expression of Major Lipid Raft Protein Raftlin in Chronic Rhinosinusitis with Nasal Polyps in Smoking and Non-Smoking Patients Correlated with Interleukin-17 and Tumor Necrosis Factor-α Levels

Lin

Tsai

et al. 2022

Biomolecules

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“…Another interesting example of the rafts’ involvement in disease is the study case of raftlin, an abundant protein in the lipid rafts of B cells and long known as essential for the functioning of these lipid rafts and the associated B-cell antigen receptor signaling [ 115 ]. The fact that the development of chronic rhinosinusitis with nasal polyps is related to the deficiency of raftlin in the nasal polyp tissue [ 116 ] points to the critical role of lipid raft integrity in this tissue and disease.…”

Section: Lipid Rafts In Cell Signaling and Diseasementioning

confidence: 99%

Rafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants’ Cellular Effects

Marques-da-Silva,

Lagoa

2023

Molecules

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The plasma membrane lipid rafts are cholesterol- and sphingolipid-enriched domains that allow regularly distributed, sub-micro-sized structures englobing proteins to compartmentalize cellular processes. These membrane domains can be highly heterogeneous and dynamic, functioning as signal transduction platforms that amplify the local concentrations and signaling of individual components. Moreover, they participate in cell signaling routes that are known to be important targets of environmental toxicants affecting cell redox status and calcium homeostasis, immune regulation, and hormonal functions. In this work, the evidence that plasma membrane raft-like domains operate as hubs for toxicants’ cellular actions is discussed, and suggestions for future research are provided. Several studies address the insertion of pesticides and other organic pollutants into membranes, their accumulation in lipid rafts, or lipid rafts’ disruption by polychlorinated biphenyls (PCBs), benzo[a]pyrene (B[a]P), and even metals/metalloids. In hepatocytes, macrophages, or neurons, B[a]P, airborne particulate matter, and other toxicants caused rafts’ protein and lipid remodeling, oxidative changes, or amyloidogenesis. Different studies investigated the role of the invaginated lipid rafts present in endothelial cells in mediating the vascular inflammatory effects of PCBs. Furthermore, in vitro and in vivo data strongly implicate raft-localized NADPH oxidases, the aryl hydrocarbon receptor, caveolin-1, and protein kinases in the toxic mechanisms of occupational and environmental chemicals.

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The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps

Cited by 2 publications

References 21 publications

Expression of Major Lipid Raft Protein Raftlin in Chronic Rhinosinusitis with Nasal Polyps in Smoking and Non-Smoking Patients Correlated with Interleukin-17 and Tumor Necrosis Factor-α Levels

Expression of Major Lipid Raft Protein Raftlin in Chronic Rhinosinusitis with Nasal Polyps in Smoking and Non-Smoking Patients Correlated with Interleukin-17 and Tumor Necrosis Factor-α Levels

Rafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants’ Cellular Effects

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