Increased oxidative stress is a widely accepted participant in the development and progression of diabetes and its complications. The present study has been undertaken to evaluate oxidative stress in type 2 diabetes mellitus and effect of vitamin E supplementation on oxidative stress. In all 120 subjects were enrolled in the present study, 40 subjects are age and sex matched controls. Test group comprised of clinically diagnosed (n = 80) type 2 diabetic patients. Biochemical parameters like serum MDA, nitric oxide, superoxide dismutase, erythrocyte reduced glutathione and platelet aggregation were analyzed in control and diabetic group. Test group is further categorized as Group I (n = 40) diabetics were treated by only hypoglycemic drugs and Group II (n = 40) diabetics were treated by hypoglycemic drugs with vitamin E supplementation. All above biochemical parameters were again reassessed after 3 months follow-up in both group and its values were compared with its respective baseline levels. The study shows, reduction of oxidative stress, improvement in antioxidant enzymes and endothelial dysfunction in group II, those were on treatment of hypoglycemic drugs along with vitamin E supplementation. Hence the present study may conclude that vitamin E supplementation along with hypoglycemic drugs may be beneficial to type 2 DM patients to minimize vascular complications.

Background: Hughling Jackson in 1870 described first "seizures as intermittent derangement of central nervous system and abnormal and excessive discharge of central nervous tissue on muscles" and the same was refined further. Average incidence rate for epilepsy is 0.3-0.5% in patients. Methods: A total of 100 patients admitted with sign and symptoms suggestive of seizure disorder in tertiary care hospital during the period of 1 st December 2012 to 31 st July 2014. A detailed clinical history, examination and investigation with following patients were included in study; (1) age of the patients above 13 years; (2) patient present with history of seizure the cross sectional observational study was carried out at Dr.

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These results from a representative sample of Solapur division railway employees show that the MeTs is highly prevalent mainly in sedentary workers aged 45 years or older. The large numbers of Indian Railway employees with the MeTs may carry important implications for the health care sector.

BACKGROUND: Dyke-Davidoff-Masson Syndrome (DDMS) is a rare neurological condition characterized by drug-resistance seizures, hemiparesis, mental retardation, facial asymmetry, and intellectual disabilities. On brain imaging, the disease is characterized by cerebral hemi atrophy with ipsilateral calvarial thickening and hyperpneumotisation of paranasal sinuses or mastoid air cells. INTRODUCTION: we describe a rare case of Dyke Davidoff Masson syndrome with an unusual cause of refractory seizure in an adolescent. Diagnosis: DDMS was diagnosed from its manifestations, biochemistry indexes, and imaging (computed tomography angiography, magnetic resonance venography, and so on). Interventions: Several drugs are used to treat the disease, including valproate, carbamazepine, topiramate, and levetiracetam. Outcomes: Under the medicine treatment of sodium valproate, levetiracetam and carbamazepine, the patient experienced generalized tonic clonic seizure seizures approximately once or twice per month that lasted 30 to 60seconds each without any complications observed during a follow-up period of. CONCLUSIONS: It was concluded early diagnosis and pharmacotherapy are the keys to preventing intellectual decline in DDMS patients. Moreover, the combination of sodium valproate, levetiracetam and carbamazepine could signicantly reduce the frequency and duration of seizures, despite not eliminating them completely24months