The purpose of this study was to analyze the relevance of introducing the maximal power (P(m)) into a critical-power model. The aims were to compare the P(m) with the instantaneous maximal power (P(max)) and to determine how the P(m) affected other model parameters: the critical power ( P(c)) and a constant amount of work performed over P(c)(W'). Twelve subjects [22.9 (1.6) years, 179 (7) cm, 74.1 (8.9) kg, 49.4 (3.6) ml/min/kg] completed one 15 W/min ramp test to assess their ventilatory threshold (VT), five or six constant-power to exhaustion tests with one to measure the maximal accumulated oxygen deficit (MAOD), and six 5-s all-out friction-loaded tests to measure P(max) at 75 rpm, which was the pedaling frequency during tests. The power and time to exhaustion values were fitted to a 2-parameter hyperbolic model (NLin-2), a 3-parameter hyperbolic model (NLin-3) and a 3-parameter exponential model (EXP). The P(m) values from NLin-3 [760 (702) W] and EXP [431 (106) W] were not significantly correlated with the P(max) at 75 rpm [876 (82) W]. The P(c) value estimated from NLin-3 [186 (47) W] was not significantly correlated with the power at VT [225 (32) W], contrary to other models ( P <0.001). The W' from NLin-2 [25.7 (5.7) kJ] was greater than the MAOD [14.3 (2.7) kJ, P < 0.001] with a significant correlation between them (R = 0.76, P <0.01). For NLin-3, computation of W (P > P c), the amount of work done over P(C), yielded results similar to the W' value from NLin-2: 27.8 (7.4) kJ, which correlated significantly with the MAOD (R = 0.72, P <0.01). In conclusion, the P(m) was not related to the maximal instantaneous power and did not improve the correlations between other model parameters and physiological variables.

The aim of this study was to compare the lactate indices provided by single- and double-breakpoint models with lactate thresholds obtained with conventional methods. Arterial samples for the determination of lactate concentrations were drawn from eight participants at rest and every minute during a ramp test (15 W x min(-1)) on a cycle ergometer. Lactate thresholds were determined from a blood lactate concentration equal to 4 mM (LT(4)), from an increase of 1 mM above the resting level (Delta1 mM), and from indirect methods using ventilatory parameters. Other indices were computed from the modelling of the lactate curve using an exponential function (LSI), a polynomial function (Dmax), a semi-log model (SLog), a parabola plus delay model (Mod P), and a two-breakpoint model (Mod M). Mod P and Mod M showed poor agreement with the other methods. LT(4), Dmax, LSI, and respiratory exchange ratio equal to 1 were correlated with each other (0.81

Purpose Given the Veterans Affairs Boston Healthcare System's recent introduction of single-use Tonosafe disposable tonometer prisms as an alternative to Goldmann applanation tonometers (GATs), this study had two aims: to conduct a large-scale quality assurance trial to assess the reliability of intraocular pressure (IOP) measurements of the Tonosafe disposable tonometer compared with GAT, particularly at extremes of pressure; to evaluate the suitability of Tonosafe disposable tonometer prisms as an acceptable substitute for GATs and for clinic-wide implementation in an academic tertiary referral setting. Methods Ophthalmology resident physicians measured the IOPs of patients in general and specialty eye clinics with the Tonosafe disposable tonometer and GAT. Tonosafe test-retest reliability data were also collected. A retrospective review of patient charts and data analysis were performed to determine the reliability of measurements. Results The IOPs of 652 eyes (326 patients) were measured with both GAT and Tonosafe, with a range of 3-34 mm Hg. Linear regression analysis showed R ¼ 0.93, slope ¼ 0.91, both of which supported the proposed hypothesis, and the y-intercept ¼ À1.05 was significantly different from the hypothesized value. The Tonosafe test-retest repeatability (40 eyes of 40 patients), r ¼ 0.977, was very high, which was further supported by linear regression slope ¼ 0.993, y-intercept ¼ 0.118, and a Tonosafe repeatability coefficient of 2.06, similar to GAT repeatability. Conclusions The IOP measurements by Tonosafe disposable prisms correlated closely with Goldmann measurements, with similar repeated measurement variability to GAT. This suggests that the Tonosafe is an acceptable substitute for GAT to measure IOP in ophthalmology clinic settings.

This study aimed to estimate the power/time relationship from a single ramp test (RT) assuming critical power (Pc) from ventilatory threshold (VT) and energy reserve (W') from total work during RT These estimates from single RT were compared to those from a series of 4 constant power exercises (CPT) and from a series of 4 RT. Only W' from CPT was higher than from the series of RT and from single RT using VT (p < 0.05).

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The hostile conditions at informal and illegal mining sites in the Amazonian forest erode the miner’s health, exposing workers to a broad range of diseases because most of the gold is extracted using mercury (Hg). The Hg vapor used daily at gold panning sites presents an environmental threat to the ecosystems and human health. We report the case of a 58-year-old man who has worked in gold panning for over 30 years, presented with diffuse interstitial pneumonia characterized by bilateral images of ground glass and mosaic opacities on the chest CT scan. Based on the negative differential diagnosis (cardiovascular, infectious, autoimmune or cancer), the context of chronic exposure to Hg in a patient who has been working for decades on illegal gold panning sites, we concluded to a chronic form of heavy metal hypersensitivity pneumonia. This hypothesis was supported by high levels of mercury in blood and urine. Mercury hypersensitivity pneumonia might be more frequent than presently thought with thousands of workers chronically exposed to high mercury concentrations among others pollutants. Medical practitioners should systematically seek for chronic respiratory illnesses associated with pollutants exposure in these vulnerable workers with poor health.