Several studies are going on to study the effects of transfusing stored RBCs on recipients. Several biochemical changes occur in stored blood, which may have some medical effects on the recipients. The biochemical changes may vary from donar to donar as well as from Blood bank to Blood bank. Also effects of transfused RBCs will vary from recipient to recipient. Lot of clinical trial should be taken before assessing the safety of stored RBCs.
OBJECTIVESTo study the various biochemical changes occurring in a stored whole blood.
MATERIAL AND METHODSAnalysis of biochemical changes occurring in stored whole blood in 20 voluntary donars was done in a Blood bank of a Tertiary Hospital.
RESULTSOf the 6 biochemical parameters studied, only significant changes were seen in potassium and albumin after storage. There was a significant decrease in albumin concentration and steady increase in potassium values.
CONCLUSIONCertain biochemical changes do occur in stored whole blood over a duration of storage. As the demand for blood is high due to various medical conditions, the treating consultant should be aware of the biochemical changes seen in stored whole blood.
Adolescence age group has significant impact of advertizing industry for use of soft drink and junk food. Present study is aimed to find out the alteration in the bone markers in medical and dental students, who regularly consume soft drinks. Students from our institute were divided (n = 200) in two groups. Group A – Students who consume 200 ml or less than 200 ml of soft drink in a week. Group B -Students consuming more than 200 ml of either ‘regular’ soft drink (B1) or ‘diet’ soft drink (B2) per day There is a significant decrease in the levels of bone density, calcium, phosphorous, vitamin D and increase in the activity of alkaline phosphatase in Group B2 than group A as well as B1.Diet soft drinks are consumed instead of regular soft drinks, the decrease in the pH due to phosphoric acid and aspartame; may lead to bone demineralization resulting into decreased bone density. Inhibition of 1alpha hydroxylase may get inhibited due to acid pH caused by phosphoric acid from soft drinks. These changes may lead to develop tendency of bone fractures in the future life.
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