The article presents clinical studies of low-intensity laser irradiation (LILI). The effect of laser therapy in male infertility is shown. Russian and foreign sources of literature on this topic have been analyzed. (For citation: Moskvin SV, Borovets SYu, Toropov VA. Сlinical justification of laser therapy efficiency of men’s infertility. Urologicheskie vedomosti. 2018;8(1):47-55. doi: 10.17816/uroved8147-55).