Сlinical justification of laser therapy efficiency of men’s infertility

Москвин, С. В.; Владимирович, Москвин Сергей; Borovets, S. Yu.; Юрьевич, Боровец Сергей; Toropov, Viktor A.; Александрович, Торопов Виктор

doi:10.17816/uroved8147-55

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“…Уровень фертильности во многих странах мира достаточно низкий, что ведет к серьезным демографическим и социальным последствиям [2]. В 30-50 % случаев бесплодие в браке обусловлено мужским фактором инфертильности [2,3].…”

Section: Introductionunclassified

“…Мужское бесплодие является полиэтиологичным заболеванием, которое может быть результатом различных расстройств [3][4][5]. Чаще всего причинами секреторной формы бесплодия являются варикоцеле, урогенитальные инфекции, гормональные, аутоиммунные и генетические нарушения.…”

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Regarding the efficacy of low-level laser therapy in infrared spectrum in male secretory infertility

et al. 2020

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The aim of study was to assess the effect of low-level laser therapy (LLLT) in infrared spectrum on the main sperm parameters, sperm DNA fragmentation, MAR-test in men with nonobstructive pathozoospermia. Patients and methods. The study included 50 men from 23 to 40 years old (average age 31.0 5.4), suffering from secretory infertility. Physical examination, semen analysis, MAR-test, sperm DNA fragmentation analysis, male hormone panel, assessment of prostate microbiocenosis, testes and prostate tumor markers, ultrasound examination with color flow mapping were performed. After the examination patients had a course of LLLT in infrared spectrum on a Rubin-C device. 10 laser therapy procedures were carried out every two days with active luminescence for 3 minutes of both testicles. Control examination was done immediately after the LLLT, within one and two months. Results. Increase in sperm concentration (by an average of 25%), active mobile sperm forms (by an average of 25%), morphologically normal sperm forms (by an average of 58%) was noticed after the LLLT. MAR-test decreased by an average of 69% after the therapy. From 10 patients with initially increased sperm DNA fragmentation level, in 9 patients its level became normal after the treatment. Increase in concentration of total and free testosterone in blood plasma was noticed within one month after the LLLT. As a result of the treatment pregnancies developed in 11 (22%) out of 50 couples. Conclusions. LLLT in infrared spectrum improves sperm quality in patients with secretory infertility, decreases MAR-test level, normalizes sperm DNA-fragmentation level, increases chances of pregnancy in reproductive cycle, which allows to recommend this method as preparation for assisted reproductive technologies.

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Regarding the efficacy of low-level laser therapy in infrared spectrum in male secretory infertility

et al. 2020

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Combined treatment of idiopathic male infertility using low-intensity laser therapy and complex prostate peptides: single-centre experience

Potapova

Borovets

2023

Vestn. Urol.

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Introduction. The study of effective and safe combined methods of conservative treatment of idiopathic male infertility is of great interest.Objective. To evaluate the effectiveness of the combined use of low-level laser therapy (LLLT) in the infrared (IR) spectrum and bioregulatory therapy with complex prostate peptides on the semen parameters and sperm DNA fragmentation (SDNAF) in men with idiopathic infertility.Materials & methods. The study is based on the results of examination and treatment of 97 men with idiopathic infertility. Prior to the start of treatment, all patients were divided into three groups by randomization. Patients in group 1 (n = 34) underwent a course of LLLT in the IR spectrum consisting of 10 procedures q.o.d. Patients in group 2 (n = 31) were prescribed complex prostate peptides Supp. Prostatilen® AC (30 + 180 mg) PR q.h.s. FXD, with a repeat of the course of treatment after 5 days. Patients in group 3 (n = 32) underwent combined treatment: LLLT sessions in the IR spectrum (10 procedures q.o.d.) and a course of Supp. Prostatilen® AC (30 + 180 mg) PR q.h.s. FXD, with a repeat of the course of treatment with peptides according to the same scheme after 5 days. Control examination of patients in all groups was carried out two months after the end of treatment.Results. As a result of treatment of patients in groups 1, 2, and 3, a significant improvement in the main semen parameters, a decrease in the grade of pathological SDNAF, an increase in serum total and free testosterone concentration (p < 0.05) were observed. A comparative statistical analysis of the results obtained in three groups of patients showed that the combined treatment of patients of group 3, who were prescribed a course of LLLT in combination with complex prostate peptides Supp. Prostatilen® AC, was significantly more effective in improving concentration (p < 0.01) and progressive sperm motility (p < 0.01), as well as a decrease in the grade of pathological SDNAF (p < 0.05), than in groups 1 and 2.Conclusion. Combined therapy that includes complex prostate peptides and LLLT in the IR spectrum improves the main semen parameters and reduces the grade of pathological SDNAF in men with idiopathic infertility.

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Сlinical justification of laser therapy efficiency of men’s infertility

Cited by 2 publications

References 1 publication

Regarding the efficacy of low-level laser therapy in infrared spectrum in male secretory infertility

Regarding the efficacy of low-level laser therapy in infrared spectrum in male secretory infertility

Combined treatment of idiopathic male infertility using low-intensity laser therapy and complex prostate peptides: single-centre experience

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