Objectives To determine the diagnostic value of ProEx C in the detection of cervical squamous epithelial lesions. Materials and methods A cross-sectional study was conducted on 60 cataloged cervical biopsy specimens. The specimens were received from incident cases for routine histopathological evaluation in MS Ramaiah Hospital. Immunohistochemical examination was performed on paraffin biopsy blocks of the specimen for nuclear and cytosolic staining with ProEx C. From the data, the proportion of positive staining cells and the average intensity of staining were assessed. Results As per this study, the sensitivity and specificity of ProEx C were found to be 95 and 83%, respectively. Conclusion ProEx C is an ascertained highly sensitive and specific marker. This will help to overcome the drawbacks of basic screening methods in terms of inter- and intra-observer variations and false-positive and false-negative values, and either replace or complement the less economical human papillomavirus (HPV) DNA testing in the triage for developing nations. Clinical significance The use of ProEx C as an immunohistochemical marker is a highly reliable indicator of not only the presence of cervical squamous epithelial lesions but also the grade of the lesion. With high positive and negative predictive values for dysplasia and invasive carcinomas as well, ProEx C serves as an excellent diagnostic tool for cervical intraepithelial lesions. How to cite this article Nayak AU, Muthukumar V, Sridhar HS, et al. Efficacy of ProEx C in Detecting Cervical Squamous Epithelial Lesions: A Cross-sectional Study. J South Asian Feder Obst Gynae 2020;12(6):383–386.

Back ground: The carotico clinoid foramen is formed by an osseous bridge between tip of the middle and anterior clinoid processes of the sphenoid bone and transmits one of the segments of internal carotid artery (ICA).Context: The existence of a bony or osseous carotico clinoid foramen may cause compression, tightening or stretching of the ICA, especially of the clinoidal segment and cause complications in regional surgery.Purpose: The present study is an effort to study the carotico clinoid foramen in skulls and observe various parameters like presence or absence, unilateral or bilateral, complete or incomplete, extent, dimensions of the ligament, dimensions of the foramen and sexual dominance.Results: Presence of complete foramen was found in 12% and incomplete foramen was 26%. The mean width and thickness of the ligaments was found to be greater on the left side and greater in males. The size of the foramen was found to be more on the left side and in males. Complete foramina were found to be more in males while incomplete foramina were found equally in both sexes. Unilateral foramen were found to be more in females while bilateral foramina were found to be more in males. Conclusion:Considering the fact that most of the anatomy text books do not provide a detailed description of the carotico clinoid ligament or foramen, the present study proves especially relevant to neurosurgeons in day to day clinical practice.Implication: Knowledge of the prevalence of carotico clinoid foramen helps the neuro-surgeons for pre-operative scanning and precautions can be taken to prevent fatal complications during surgery. Further, removal of the anterior clinoid process is an important step in regional surgery, for which additional risk is involved. Therefore detailed anatomical knowledge of the carotico clinoid foramen is of utmost importance, to increase the success of regional surgeries.KEY WORDS: carotico clinoid foramen, clinoid process, internal carotid artery, clinoidectomy, interclinoid foramen.