As a class, octahydrophenanthrene lactones, podolactones, and related podocarpic acid derivatives have been reported to possess a wide variety of biological activities, including antileukemic activity, inhibition of plant cell growth, insect toxicity and antifungal properties. In the present study, a series of synthetic derivatives of podocarpic acid have been prepared by chemical synthesis and evaluated with respect to their ability to inhibit fungal growth. These compounds were evaluated against the Oomycetes-Phytophthora cactorum , Saprolesnia ferax, and Achlya bisexualis and the Ascomycetes-Gibberella fujikuroi. The results of these studies indicate that several of these new synthetic derivatives possess significant antifungal properties.
Nitration of Polycyclic Aromatic Hydrocarbons Using a SupportedCatalyst.-The nitration catalyst is prepared by soaking silica gel in sulfuric acid, filtering the silica gel, and drying it at room temperature for 5 hours and at 130 • C for 24 hours. Although the catalyst is hygroscopic, it retains its activity for a long time when it is protected from atmospheric moisture. -(SMITH, AMY C.; NARVAEZ, LORENA D.; AKINS, BRIDGET G.; LANGFORD, MOSES M.; GARY, THOMAS; GEISLER, VICTORIA J.; KHAN, FAROOQ A.; Synth. Commun. 29 (1999) 23, 4187-4192; Dep. Chem., State Univ. West Ga., Carrollton 30118, USA; EN)
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