Synthesis and Fungistatic Activity of Podocarpic Acid Derivatives

Abstract

As a class, octahydrophenanthrene lactones, podolactones, and related podocarpic acid derivatives have been reported to possess a wide variety of biological activities, including antileukemic activity, inhibition of plant cell growth, insect toxicity and antifungal properties. In the present study, a series of synthetic derivatives of podocarpic acid have been prepared by chemical synthesis and evaluated with respect to their ability to inhibit fungal growth. These compounds were evaluated against the Oomycetes-Phytophthora cactorum , Saprolesnia ferax, and Achlya bisexualis and the Ascomycetes-Gibberella fujikuroi. The results of these studies indicate that several of these new synthetic derivatives possess significant antifungal properties.

Microbial Transformation of Podocarpic Acid and Evaluation of Transformation Products for Antioxidant Activity

“…Others, including a podocarpic acid anhydride, have been shown to be liver X receptor α and β agonists and thus could be potentially useful in the development of drugs for the treatment of atherosclerosis [11][12][13][14]. Some analogues have shown antiviral [15], antitumor [16], antimicrobial [17,18], and cytotoxic activities [19,20]. This article describes the metabolic study of podocarpic acid using Mucor ramannianus ATCC 9628 and Beauveria bassiana ATCC 7159 for production of new metabolites and the testing of these metabolites for antioxidant activity.…”