Summary: Acute toxicity study of potassium permanganate was carried out in Swiss albino mice. Potassium permanganate was administered at dose rate of 0.0, 500, 1000, 1500, 2000, 2500, 3000 and 3500mg/kg body weight to groups 1, 2, 3, 4, 5, 6, 7 and 8, ten per group for LD 50 determination. The dead animals were posted for gross lesions. A predetermined dose of 160mg/kg of the chemical was administered to experimental group of 12 mice, whereas control group of 12 mice received 16ml/kg body weight of distilled water for a period of 7 days. Grower's marsh and water were provided ad libitum. The animals were weighed daily before administration of potassium permanganate. On the eighth day 1ml of blood sample was collected from both control and experimental mice for haematology and plasma biochemistry into ethylene diamine tetraacetic acid bottles. The median lethal dose (LD 50 ) was estimated at 1449.7mg/kg body weight. There was no significant difference between the mean weight of control and experimental group. Haematological and biochemical parameters of both control and experimental groups did not increase significantly though there was a significant (P<0.05) decrease in chloride ion level in plasma. Toxicity signs observed are rapid and shallow respiration, rough hair coat, dullness, diarrhoea, bloat, gastroenteritis, congestion of liver, paleness of lungs and hypochloraemia.
Lead had been known to be toxic since pre-antiquity. It causes neurodevelopmental, cardiovascular and renal pathologies. Other toxicological studies of lead (Pb) salts are studied in laboratory animals such as rat, mice, hamsters, rabbits and monkeys; however, there is paucity of information on the median lethal dose (LD 50) of Pb salts in rabbits especially when used as a model for molecular studies of Pb toxicity. In view of this, oral LD 50 of lead (Pb) diacetate [Pb(CH 3 COO) 2 ] was determined in both young (6 weeks old, weighing 0.40 ± 0.03 kg) and adult (34 weeks old, weighing 1.63 ± 0.10 kg), male and female New Zealand White (NZW) rabbits (Oryctolagus cuniculus) using the revised arithmetic method of Up-and-Down Procedure (UDP). The estimated LD 50 of Pb diacetate in young male and female NZW rabbits was 1214.20 ± 275.80 and 1214.20 ± 275.80 mg/kg body weight respectively. Also, the LD 50 of the adult male and female rabbits was 1503.30 ± 342.90 and 1792.50 ± 354.40 mg/kg body weight respectively. Similarities in the estimated LD 50 of the young rabbits could be attributed to poorly developed xenobiotic metabolic processes. Sex-dimorphism in the toxicity of Pb diacetate was observed in the adult animals, where the male animals were found to be more sensitive to the toxicant than the female. Hence, Pb diacetate is moderately toxic in NZW Rabbits according to "Gosselin, Smith and Hodge scale" of toxicity rating.
Objective: This case report describes the surgical management of a clinical case of sertoli cell tumor in a Lhasa Apso breed of dog Materials and methods: A 4-year old sexually intact Lhasa apso was presented with complaints of alopecia, shivering, reduced appeteite and swelling of the inguinal region. The dog was subjected to thorough physical, Hematological, Histopathological and Radiographic evaluations. Results: The vital parameters were within normal values. Hematological analysis revealed anemia and thrombocytopenia as the common findings. Abdominal radiography showed a soft tissue mass in the inguinal region. Histopathology revealed testicular hypoplasia with poorly developed seminiferous tubule with no discernible lumen or spermatozoa and several proliferating sertoli cells on the lining of the basement membrane of the seminiferous tubules which is diagnostic of sertoli cell tumor. Decision to surgically excise the tumor was arrived at. The anesthetic protocol involved premedication with atropine sulphate dosed at 0.04 mg/kg bwt and xylazine dosed at 2 mg/kg bwt intramuscularly (IM). Anesthesia was induced and maintained with propofol dosed at 6 mg/kg bwt intravenously (IV). The tumor mass was surgically excised. Broad spectrum antibiotics (penstrep) and analgesic (pentazocine) were administered for 5 days IM. Conclusion: The condition of the dog improved remarkably and it was discharged on postoperative day 10.
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