The effect of ethyl acetate extract of Ficus thonningii (Blume) leaves on erythrocyte osmotic fragility and haematological parameters in acetaminophen-treated rats

Ahur, Victor Masekaven; Madubunyi, Ifeanyi Innocent; Adenkola, A.Y.; Udem, Samuel Chukwuneke

doi:10.1007/s00580-010-1107-1

Cited by 17 publications

(26 citation statements)

References 15 publications

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“…Coker et al, (2009) reported that F. thonningii extracts had no deleterious effects on the haematinic value, whilst ethyl acetate leaf extracts of F. thonningii were reported to improve red blood cell counts in acetaminophen-treated rats (Ahur et al, 2010). Contrary to these reports, the results obtained in this study showed a significant reduction in the packed cell volumes of rats treated with high aqueous doses of F. thonningii.…”

Section: Discussioncontrasting

confidence: 84%

“…Previous studies on the phyto-chemistry of F. thonningii have also reported the presence of these phytochemicals (Ndukwe et al, 2007;Usman et al, 2009;Ahur et al, 2010). These phyto-chemicals could be responsible for the broad pharmacological activity of F. thonningii that supports its widespread use in African traditional medicine.…”

Section: Discussionmentioning

confidence: 81%

“…Tannins, alkaloids, terpenes, saponins and cardiac glycosides have also been isolated from various parts of F. thonningii (Ndukwe et al, 2007, Usman et al, 2009Bamikole et al, 2004). F. thonningii leaves contain other secondary metabolites such as lignins, lignans and active proteins such as ficin, which add to their pharmacological and biological activity (Ahur et al, 2010). F. thonningii leaves have also been shown to contain essential oils which are composed mainly of 6, 10, 14 trimethyl-2-pentadecanone (18.8%), phytol (14.7 %), acorenone (7.6 %) and β-gurjunene (6.3%), (Ogunwande et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Effects Of <i>Ficus Thonningii</i> Extracts On The Gastrointestinal Tract And Clinical Biochemistry Of Suckling Rats

Dangarembizi

Erlwanger²,

Chivandi³

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Ficus thonningii is commonly used in traditional medicine across the African continent. We investigated the effects of crude Ficus thonningii extracts on growth, morphology and morphometry of the abdominal viscera and clinical biochemistry of neonatal rats. Materials and Methods: Forty, 6-day old Sprague Dawley rat pups were orally gavaged once daily with either low (50 mg.kg -1 b.w) or high (500 mg.kg -1 b.w) doses of aqueous or methanolic F. thonningii leaf extracts while the control received distilled water. After 7 days of treatment, the pups were euthanased and gross morphometric measurements of the abdominal visceral organs were recorded. Samples of the liver, caecum and proximal small intestine were processed for histology. Plasma biochemical parameters were analysed colorimetrically. Results: High methanolic doses of F. thonningii extracts exhibited trophic effects on the stomach while both aqueous and methanolic extracts had trophic effects on the ceacal mucosa of rats. No significant growth-promoting effects were observed in other visceral organs. Histological analysis revealed no mucosal damage or necrosis. Clinical biochemistry parameters were not abnormally altered. There was a significant decrease (p<0.05, ANOVA) in the plasma concentration of non-fasting glucose in the high methanolic group but triglycerides and cholesterol were unaltered. Conclusion:The findings suggest that at low doses, F. thonningii extracts can be safely used without the risk of any disruption in the structural integrity of the neonatal rat GIT and function of the liver and kidneys.

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Section: Discussioncontrasting

confidence: 84%

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Effects Of <i>Ficus Thonningii</i> Extracts On The Gastrointestinal Tract And Clinical Biochemistry Of Suckling Rats

Dangarembizi

Erlwanger²,

Chivandi³

2014

Afr. J. Trad. Compl. Alt. Med.

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“…In Nigeria, a maceration of the leaves is used for treating stomach pains, gastritis, gastric ulcers and other stomach conditions in animals (Nwude and Ibrahim, 1980). The leaves can also be used for treating liver disorders and disease conditions associated with jaundice (Ahur et al, 2010). Other medicinal uses of the leaves reported include treatment of bone movement disorders, ringworm, thrush, scabies and athlete's foot rot (Moshi et al, 2009;Alawa et al, 2002).…”

Section: Ethnomedicinal Uses Leavesmentioning

confidence: 99%

“…Although all parts of the F. thonningii are medicinally useful, the latex-rich leaves are preferred because latex has been traditionally associated with potency (Ahur et al, 2010). Macerations of fresh F. thonningii leaves, taken orally, have been used by traditional healers for treating diarrhoea, gonorrhoea and diabetes mellitus (Njoronge and Kibunga, 2007).…”

Section: Ethnomedicinal Uses Leavesmentioning

confidence: 99%

Phytochemistry, pharmacology and ethnomedicinal uses of Ficus thonningii (Blume moraceae): A review

Dangarembizi¹,

Erlwanger²,

Moyo³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The common wild fig, Ficus thonningii, is extensively used in African ethnomedicine for treating a number of disease conditions which include diarrhoea, urinary tract infections, diabetes mellitus, gonorrhoea, respiratory infections, and mental illnesses. This review aims to present a logical analysis of the nutritional, phytochemical and pharmacological properties of F. thonningii in relation to its therapeutic applications. A bibliographic analysis of the uses, phytochemical constituents and phytophamacological properties of Ficus thonningii was carried out using published papers, medicinal plant databases and various ethnobotanical and ethnopharmacological books. Ficus thonningii contains various bioactive compounds which include alkaloids, terpenoids, flavonoids, tannins and active proteins, all of which contribute to its curative properties. In vitro and in vivo pharmacological studies revealed that F. thonningii possesses antimicrobial, antidiarrhoeal, antihelmintic, antioxidant, anti-inflammatory and analgesic properties. Acute and sub-chronic toxicity studies have shown that Ficus thonningii is non-toxic if administered orally in low doses. Scientific research has validated the ethnomedicinal claims that Ficus thonningii is useful in disease management. However, there is need to continue identifying, isolating and quantifying the active principles and possibly determine the mechanisms underlying its curative properties.

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African Medicinal Plants Useful for Cognition and Memory: Therapeutic Implications for Alzheimer’s Disease

Enogieru

Momodu

2021

Bot. Rev.

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The effect of ethyl acetate extract of Ficus thonningii (Blume) leaves on erythrocyte osmotic fragility and haematological parameters in acetaminophen-treated rats

Cited by 17 publications

References 15 publications

Effects Of <i>Ficus Thonningii</i> Extracts On The Gastrointestinal Tract And Clinical Biochemistry Of Suckling Rats

Effects Of <i>Ficus Thonningii</i> Extracts On The Gastrointestinal Tract And Clinical Biochemistry Of Suckling Rats

Phytochemistry, pharmacology and ethnomedicinal uses of Ficus thonningii (Blume moraceae): A review

African Medicinal Plants Useful for Cognition and Memory: Therapeutic Implications for Alzheimer’s Disease

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