The paper considers the method, based on multifractal (MF) analysis, for classifying the shape of tissue cells from microscopis images, identifying the primary cancer in cases of metastasis bone disease. Diagnosis of primary cancer is of great importance, because further treatment depends on how successful and accurate that diagnosis is. This method can be applied as an additional and objective tool in primary cancer diagnosis, as well as in decreasing of the subjective factor and error probability. The method is tested over a large number (1050) of clinical cases from the Institute of Pathology, University of Belgrade. The results of computer-aided analysis of images have been presented and discussed.

The lethal outcome ensues within less than 2 years in all patients.

Cemento-ossifying fibroma (COF) belongs to the group of bone-related lesions of the oral cavity. The aim of this study was refine its histologic features and to correlate histopathological picture and clinical behavior of the tumor. The quantity of bone spherules, their cellularity, the existence of hemorrhage, inflammation, and endochondral ossification in the stroma of the tumor were analyzed and correlated with patients main symptoms of ten patients with COF. All patients had swelling that lasted between 3 and 20 months (mean 10.4 months). Other clinical symptoms were facial asymmetry, eye bulb protrusion, and teeth displacement. The evolution of the tumor was longer in the mandible (12.3 months) than in maxilla (9.5 months). The main histomorphological diagnostic criterion for COF was psammoma-like structures. In lesions with longer case history, the number of "psammomatoid" bodies was greater. In lesions with shorter course of the disease, their number was lower and stromal hemorrhage and inflammation were presented. One patient had secondary superposition of aneurysmal bone cyst in the prime COF of mandible. Histological appearance of COF may be influenced by the tumor evolution. A siginificant correlation between the clinical course of the disease and histological parameters has been certified.

Chordoma is a malignant neoplasm believed to arise from notochord remnants. Its incidence is highest in the sixth decade and is generally regarded as a locally aggressive tumor with slow progression growth rate. Its metastatic incidence ranges from 5 to 40%, and it is generally believed that metastases without local recurrence of primary neoplasm are extremely rare. We report a case of a 38-year-old male patient with solitary inguinal lymph node metastasis without local recurrence of a previously surgically treated primary sacrococcygeal chordoma.

INTRODUCTION. Cementifying fibroma (CF) is a fibro-osseous lesion which produces cementum. OBJECTIVE. The aim of the current study was to further refine its clinical and histological features and to make clinico-pathological correlations. METHOD. The authors report 10 cases of cementifying fibroma diagnosed at the Institute of Pathology, School of Medicine, University of Belgrade, during 15 years (1995-2005). RESULTS. CF showed no sex predilection (5 males and 5 females). The youngest patient was a 14-year old male, and the oldest was a 54-year old female (the average years were 27.1). The maxilla was the most frequent site (80%). Only one patient had a lesion in the baseos cranii with invasion of sella turcica. All the patients reported history of pain and oedema lasting from 3 to 20 months (medium 10.4 months). Other clinical symptoms were: face assymetry, tooth dislocation and bulbus protrusion. The evolution of the tumour was longer and clinical course indolent in the patients with the mandibular localisation (mandible - 12.3 months, maxilla - 9.5 months). Clinical course and duration of history were in correlation with the histological feature of CF. The main histomorphological diagnostic criterion for CF was psammoma-like structures. Their number and mineralisation of bone spherules varied during the tumour maturation. In old lesions, the number of ?psammomatoid? bodies increased with long anamnesis. On the contrary, dramatic clinical symptoms were described in the CF with stromal haemorrhage and inflammation. We had one patient with secondary superposition of aneurysmal bone cyst in the prime CF. CONCLUSION. Differential diagnosis of cementifying fibroma and other fibro-osseous lesions of cranial bones by histological evaluation only is often difficult and asks for permanent cooperation between clinical doctors and pathologists.