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The findings of present study could suggest a role of mast cells in regulation of cellular immune mechanisms in periapical lesions, balancing between alterative and reparatory processes in inflamed periapical tissue.

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Cemento-ossifying fibroma (COF) belongs to the group of bone-related lesions of the oral cavity. The aim of this study was refine its histologic features and to correlate histopathological picture and clinical behavior of the tumor. The quantity of bone spherules, their cellularity, the existence of hemorrhage, inflammation, and endochondral ossification in the stroma of the tumor were analyzed and correlated with patients main symptoms of ten patients with COF. All patients had swelling that lasted between 3 and 20 months (mean 10.4 months). Other clinical symptoms were facial asymmetry, eye bulb protrusion, and teeth displacement. The evolution of the tumor was longer in the mandible (12.3 months) than in maxilla (9.5 months). The main histomorphological diagnostic criterion for COF was psammoma-like structures. In lesions with longer case history, the number of "psammomatoid" bodies was greater. In lesions with shorter course of the disease, their number was lower and stromal hemorrhage and inflammation were presented. One patient had secondary superposition of aneurysmal bone cyst in the prime COF of mandible. Histological appearance of COF may be influenced by the tumor evolution. A siginificant correlation between the clinical course of the disease and histological parameters has been certified.

Oroantral fistula is pathologic communication between oral cavity and maxillary sinus, usually localized between antrum and buccal vestibulum. Persisting OAF always causes chronic maxillary sinusitis. A technique for closure of a large oroantral fistula with resorbable collagen membrane is described

The aim of histopathological investigations was to evaluate the effect of PMMA based material on bone tissue of experimental animals. In the femoral bone of laboratory Wistar rats pastes were implanted for canal obturation SEALPEX (Kerr, Romulus, USA), AH-26 (DeTrey, Zurich, Switzerland) and poly methyl metacrylate (PMMA) based material, called SPONGI CEMENT (Tomic, 1981, US PATENT 4296209). As control material sterile wax was used. The rats were sacrificed 60 days after implantation, and the material was prepared by standard histological method and hematoxillin eosine stained. The results of microscopic investigations suggested that implanted PMMA based material was in direct contact with the new completely formed bone. SEALPEX and AH-26 implanted in bone tissue of rats was surrounded with inflamed infiltrate. Implantation of wax produced fibrous tissue capsule around the material. These findings suggest biocompatibility of polymethyl metacrylate material (PMMA)

CRP levels correlate well with the severity and resolution of AOI and could be used as a reliable parameter in monitoring the effectiveness of AOI therapy.