Lesions of the deep mediastinum are often difficult to conclusively diagnose with nonendoscopic studies. Endoscopic ultrasound and endoscopic ultrasound-guided fine needle aspiration can easily access this region to aid in the diagnosis and management of these lesions.
Candida mediastinitis is a rare clinical entity associated with high mortality and morbidity. It is emerging as an important clinical entity, probably due to increased recognition of candida as a significant pathogen in mediastinitis. Candida mediastinitis is usually associated with cardiothoracic surgery, esophageal perforation, and head and neck infections. Optimal therapy for candida mediastinitis remains undefined. Aggressive, combined surgical debridement and antifungal therapy appears to be the most effective of available therapies. We report a case of spontaneous candida mediastinitis diagnosed by endoscopic ultrasound-guided, fine-needle aspiration and successfully treated with oral antifungal therapy alone.
Conclusions: Partial splenic embolization appears to demonstrate a favorable response in the recovery of thrombocytopenia in patients with metastatic disease. Recovery of platelet counts appears to be within a reasonable timeframe and allows for the safe initiation, or continuation, of systemic chemotherapy in this patient cohort with minimal delay to treatment. Overall complication profile is low.
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