The data show that profound gene expression changes occur in sun-exposed, nonlesional skin which progress further in AK lesions. The data also suggest that imiquimod may play a role in normalizing gene expression and cellular morphology in sun-damaged skin.

Conclusions: Partial splenic embolization appears to demonstrate a favorable response in the recovery of thrombocytopenia in patients with metastatic disease. Recovery of platelet counts appears to be within a reasonable timeframe and allows for the safe initiation, or continuation, of systemic chemotherapy in this patient cohort with minimal delay to treatment. Overall complication profile is low.