Background: Obstetric hysterectomy (OH) still remains lifesaving procedure. OH still poses a major obstetrical morbidity in the developing world due to lack of human, infrastructural and monetary resources. Irrespective of attempts like good antenatal care and delivery planning in modern obstetrics to prevent major obstetric complications; unfortunately, OH needs to be performed at times even today. The aim of present study was to determine the changes in the indications of obstetric hysterectomy.Methods: A retrospective review based on hospital data of all the patients’ records subjected to OH from January 1994 to September 2001 (Gr. A) and from January 2006 to December 2015 (Gr. B) was done and analyzed for incidence and changing trends in the indications.Results: The incidence of OH during two periods from January 1994 to September 2001 (Group A) and from January 2006 to December 2015 (Group B) in the Department of Obstetrics and Gynecology at Shri. Bhausaheb Hire Govt. Medical College, Dhule was 3.27/1000 and 0.97/1000 deliveries. Incidence is reduced by more than three folds. In both groups maximum patients were below 30 yrs of age and multipara. The commonest indications for OH in both groups were uterine rupture, uncontrolled Atonic PPH and placental causes. The incidence of uterine rupture as a cause for OH was reduced from 78.16% to 43.24%, while that of Atonic PPH has increased from 16.09% to 28.37% and placental causes has increased from 4.59% to 9.45%. Among the risk factors for OH, the incidence of prolonged or obstructed labour has reduced from 66.66% to 21.62% and that of malpresentations has reduced from 27.58 to 5.4%.Conclusions: There is definite reduction in the incidence of OH, frequency of uterine rupture, obstructed labor and malpresentations in Gr. B due to timely referral, improved infrastructure and transportation facilities.
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Introduction: The global pandemic COVID-19 and its uncontrolled spread and lack of effective therapeutics demand to investigate the herbal resources in search of novel, safe and potent therapeutics. Herbal medicines have proven the advantage of multi-target potential and thus can be investigated for virus-host interaction protein and viral protein targets. Objectives: Manuscript aims to provide an outcome-based analysis of studies performed towards evaluation of herbal compounds as anti-COVID agents. The studies focus on the proposed mechanism of viral inhibition by herbal compounds. Methods: The details on modern drug discovery approaches for investigation of potential antiviral agents includes in silico screening, ADMET and molecular docking studies. It helps to establish the probable mechanism of viral inhibition as well as to establish pharmacophore. The reports explaining role of herbal therapeutics/phytochemicals in antiviral drug development have been thoroughly searched. Results: The study summarizes herbal therapeutics and phytochemicals based on their antiviral properties against various pathogenic viruses. Herbal compounds that have an interesting role in the development of therapeutics and herd immunity against SARS-CoV-2 are included and discussed. Conclusion: The manuscript provides a summarized description of herbal resources and phytochemicals which are under investigation or have been investigated as potential therapeutic option for SARS-COV-2 inhibition. It will be a useful resource for researchers interested in the development of herbal therapeutics for the prevention and/or treatment of COVID-19.
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