Test de stress rénal avec la charge d'eau salée et son association avec le déclin du débit de filtration glomérulaire estimé chez les patients avec de la maladie rénale chronique en stade 1-3 L'objectif de l'étude. Le groupe KDIGO propose le DFGe et l'albuminurie pour évaluer le risque combiné des résultats cliniques. Cependant, le déclin du DFGe peut varier indépendamment du DFGe de base. On a eu le but d'améliorer l'efficacité du pronostic chez les patients avec la maladie rénale chronique de stade 1-3 à l'aide de nouveaux facteurs pronostiques significatifs de la progression de la maladie rénale chronique détectés pendant le test de stress rénal via la charge d'eau salée avec une 0,5% solution de chlorure de sodium au taux de 0,5% du poids du corps. Méthodes. Dans une étude prospective monocentrique, 108 patients atteints de maladie rénale ABSTRACT Introduction. Kidney Disease Outcomes Quality Initiative (KDIGO) Group proposes the estimated glomerular filtration rate (eGFR) and albuminuria rate for a combined risk of clinical outcomes in patients with chronic kidney disease (CKD). However, the decline rate of eGFR can vary independently of the baseline eGFR. The objective of the study was to improve the prognostic efficacy in chronic kidney disease (CKD) stage 1-3 due to new significant factors of CKD progression detected by renal stress test via the water-salt loading with 0.5 % sodium chloride solution, at a rate of 0.5% of the body weight. Material and methods. In a single-centre prospective study, during 3-year follow-up period, from January 2016 to December 2018, 108 patients with CKD stage 1-3 (a, b) were examined. There were two groups: patients with rapidly progressive CKD whose
The purpose of the study is to investigate changes in fibrinolytic and proteolytic activity of blood plasma in patients with peptic ulcer (PU) taking into account pathogenic Helicobacter pylori (Hp) strains. Materials and methods. 93 patients with PU were examined, of which 30 patients with PU and concomitant Hp cag cag A+/vac A+ (group I), 31 patients with PU and concomitant Hp cag A-/vac A- (group II), 32 patients with PU without concomitant HP infection (group III). The control group consisted of 30 healthy individuals. Fibrinolytic activity of blood plasma was investigated with the help of lysis of azofibrin (fibrin associated with the azo dye orange), which in the alkaline medium turns a bright red color. The level of total (ТFA), enzymatic (FFA) and non-enzymatic fibrinolytic activity (NFA) was evaluated. Proteolytic activity of blood plasma was determined by the lysis of azoalbumin, azocasein and azokol. Research results. The study of fibrinolytic activity of blood plasma showed that the total fibrinolytic activity of blood plasma (TFA) in all groups was significantly higher compared to the control indicators: in patients of group I by 61.5 %, in patients by 40.9 %, in patients of group III by 30.3 %, with a significant intergroup difference between the groups. The growth of TFA was mainly due to FFA. In patients of group I, FFA increased by 2.06 times (p < 0.05), and in patients of group II – by 1.79 times (p < 0.05), in patients of group IIІ – by 1.52 times (p < 0.05) compared with the control. In patients with group I, FFA increased by 12.5 % (p < 0.05) compared with group II. In all patients examined, there was an increase in the proteolytic activity of blood plasma, in particular in group I, the lysis of azoalbumin, azocasein and azocolol increased significantly 2.94 times, 2.83 times and 1.90 times, respectively, and in the patients of group II the investigated indicators increased accordingly 1.87-fold (p < 0.05), 1.96-fold (p < 0.05) and 1.40-fold (p < 0.05), in patients of group III, respectively 1.55 times (p < 0.05), 1.59 times (p < 0.05) and 1.18 times, compared to these values in almost healthy subjects. Significantly more significant changes in proteolysis were detected in the presence of pathogenic Hp strains. Conclusion. Increased proteolytic and fibrinolytic activity of blood plasma is observed in patients with PU. The presence of concomitant Hp in PU leads to more pronounced changes in proteolysis and fibrinolysis. Pathogenic strains of Hp cag cag A+/vac A+ cause significantly more abnormalities in hemostasis.
The role of nutrition in the development and prevention of atherosclerosisAn estimated 31% of the total deaths worldwide are caused due to cardiovascular diseases (CVD's) and stroke. The most contributing factor for their development is the condition called atherosclerosis.
С целью определения особенностей электро- и эхокардиографических критериев гипертрофии левого желудочка (ГЛЖ) обследовано 202 пациента с ишемической болезнью сердца, наблюдавшейся у 164 (81,19%) больных, гипертонической болезнью, из которых в 156 (77,23%)
Renal damage in patients with rheumatoid arthritis (RA) is the most frequent and serious among other systemic manifestations and holds a special place in connection with a significant impact on prognosis and approaches to therapy. Today we know that one of the main possible factors of occurrence and development of RA are external trigger factors, among which the most important factor are infectious, and its pathogenic effect on the body can be done in different ways. Based on the latest scientific evidence on the importance of infectious trigger factors in the manifestation of RA, chronic pyelonephritis among these triggers is one of the leaders. Great interest is also the probability of pyelonephritis manifestation while presence of RA. The aim: to identify predictors ofpyelonephritis manifestation in patients with rheumatoid arthritis. Materials and methods. The authors examined 31 patients with RA with presence of chronic pyelonephritis (CP), 31 patients with RA without presence of CP and 20 healthy individuals. Was used clustering and classification methods of Data Mining on indicators of lipid peroxidation of blood and urine, р2–microglobulin blood and urine, immune factors, that defined progressive CKD on the results of our previous studies (IL–1p,IL–10, TGF–р). Results. Found that patients with diagnosed RA only, mainly are included in the cluster «1» (18patients). Some of them (3 persons) classified as belonging to the cluster «2». Thus, these individuals should have two signs of disease, RA and CP, despite the fact that they have only diagnosed RA. It means that these patients are at risk of developing CP. This analysis gives grounds to consider that RA may be signs of a factor that causes manifestation of CP. It is proved that the main factor that characterizes the individuals belonging to the cluster of healthy is 2– microglobulin in the urine with the same threshold value, but factor in determining membership of a type of disease is a factor MDA of urine. Conclusion. The main predictors of pyelonephritis manifestation in patients with rheumatoid arthritis were 2– microglobulin and MDA in urine and TGF– 1 in blood. A new method of diagnosing ofprognostic factors of CP manifestation in patients with RA which is based on cluster and classification analysis makes it possible to establish the interrelation between a diagnosis of RA and caused by it manifestation of CP.
Вищий державний навчальний заклад України «Буковинський державний медичний університет»,Чернівці У статті розглянуто діагностичні методи визначення патології нирок у хворих на ревматоїдний артрит з урахуванням основних патогенетичних механізмів прогресування хронічної хвороби. Мета роботи: проаналізувати сучасні напрямки діагностики прогресування хронічної хвороби нирок у хворих на ревматоїдний артрит згідно з даними медичної літератури. У роботі наведено дані щодо важливості визначення морфофункціональних властивостей еритроцитів, низькомолекулярних білків у крові та сечі, цитокінів у крові як маркерів пошкодження нирок. З метою визначення темпів прогресування хвороб нирок з успіхом використовується динаміка показників β 2 -мікроглобулінемії та трансформуючого фактора росту β 1 плазми крові хворих. Висновок. Вивчення та впровадження нових підходів до діагностики ревматичної нефропатії сприятиме своєчасному виявленню та лікуванню даної патології. Ключові слова: хронічна хвороба нирок, ревматоїдний артрит, діагностика, β 2 -мікроглобулін, трансформуючий фактор росту β 1 .
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