Test de stress rénal avec la charge d'eau salée et son association avec le déclin du débit de filtration glomérulaire estimé chez les patients avec de la maladie rénale chronique en stade 1-3 L'objectif de l'étude. Le groupe KDIGO propose le DFGe et l'albuminurie pour évaluer le risque combiné des résultats cliniques. Cependant, le déclin du DFGe peut varier indépendamment du DFGe de base. On a eu le but d'améliorer l'efficacité du pronostic chez les patients avec la maladie rénale chronique de stade 1-3 à l'aide de nouveaux facteurs pronostiques significatifs de la progression de la maladie rénale chronique détectés pendant le test de stress rénal via la charge d'eau salée avec une 0,5% solution de chlorure de sodium au taux de 0,5% du poids du corps. Méthodes. Dans une étude prospective monocentrique, 108 patients atteints de maladie rénale ABSTRACT Introduction. Kidney Disease Outcomes Quality Initiative (KDIGO) Group proposes the estimated glomerular filtration rate (eGFR) and albuminuria rate for a combined risk of clinical outcomes in patients with chronic kidney disease (CKD). However, the decline rate of eGFR can vary independently of the baseline eGFR. The objective of the study was to improve the prognostic efficacy in chronic kidney disease (CKD) stage 1-3 due to new significant factors of CKD progression detected by renal stress test via the water-salt loading with 0.5 % sodium chloride solution, at a rate of 0.5% of the body weight. Material and methods. In a single-centre prospective study, during 3-year follow-up period, from January 2016 to December 2018, 108 patients with CKD stage 1-3 (a, b) were examined. There were two groups: patients with rapidly progressive CKD whose
Renal damage in patients with rheumatoid arthritis (RA) is the most frequent and serious among other systemic manifestations and holds a special place in connection with a significant impact on prognosis and approaches to therapy.
Today we know that one of the main possible factors of occurrence and development of RA are external trigger factors, among which the most important factor are infectious, and its pathogenic effect on the body can be done in different ways. Based on the latest scientific evidence on the importance of infectious trigger factors in the manifestation of RA, chronic pyelonephritis among these triggers is one of the leaders. Great interest is also the probability of pyelonephritis manifestation while presence of RA.
The aim: to identify predictors ofpyelonephritis manifestation in patients with rheumatoid arthritis.
Materials and methods. The authors examined 31 patients with RA with presence of chronic pyelonephritis (CP), 31 patients with RA without presence of CP and 20 healthy individuals. Was used clustering and classification methods of Data Mining on indicators of lipid peroxidation of blood and urine, р2–microglobulin blood and urine, immune factors, that defined progressive CKD on the results of our previous studies (IL–1p,IL–10, TGF–р).
Results. Found that patients with diagnosed RA only, mainly are included in the cluster «1» (18patients). Some of them (3 persons) classified as belonging to the cluster «2». Thus, these individuals should have two signs of disease, RA and CP, despite the fact that they have only diagnosed RA. It means that these patients are at risk of developing CP. This analysis gives grounds to consider that RA may be signs of a factor that causes manifestation of CP.
It is proved that the main factor that characterizes the individuals belonging to the cluster of healthy is 2– microglobulin in the urine with the same threshold value, but factor in determining membership of a type of disease is a factor MDA of urine.
Conclusion. The main predictors of pyelonephritis manifestation in patients with rheumatoid arthritis were 2– microglobulin and MDA in urine and TGF– 1 in blood. A new method of diagnosing ofprognostic factors of CP manifestation in patients with RA which is based on cluster and classification analysis makes it possible to establish the interrelation between a diagnosis of RA and caused by it manifestation of CP.
The role of nutrition in the development and prevention of atherosclerosisAn estimated 31% of the total deaths worldwide are caused due to cardiovascular diseases (CVD's) and stroke. The most contributing factor for their development is the condition called atherosclerosis.
С целью определения особенностей электро- и эхокардиографических критериев гипертрофии левого желудочка (ГЛЖ) обследовано 202 пациента с ишемической болезнью сердца, наблюдавшейся у 164 (81,19%) больных, гипертонической болезнью, из которых в 156 (77,23%)
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