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Objective:To evaluate the antidiabetic activity of ethanolic extract of Dioscorea alata in glucose loaded and alloxan induced diabetic rats.Materials and Methods:The authenticated tubers of D. alata (DA) (JSSCPDP/2008/157) were collected from Dharmapuri, Tamil Nadu. The ethanol extract was tested for hypoglycemic activity in normal rats. In oral glucose tolerance test, glucose (3 g/kg, p.o.) was administered to non diabetic control, metformin (250 mg/kg, p.o.) and DA extract (100 and 200 mg/kg, p.o.) to treat treated rats. Diabetes mellitus was induced by alloxan monohydrate (120 mg/kg, i.p.) in physiological saline after overnight fasting for 18 hours. DA extract (100 and 200 mg/kg, p.o.) and standard drug metformin (250 mg/kg, p.o.) were administered to diabetic rats for 21 days. Fasting blood glucose level and changes in body weight were measured on days 0, 7, 14, and 21. At the end of 21st day, serum lipid profile, total protein, albumin, and creatinine were assessed.Results:In glucose loaded normal rats, the treatment with the extract of DA had shown a highly significant reduction (P < 0.001) in blood glucose levels at the doses of 100 and 200 mg/kg, respectively. The extract did not produce hypoglycemic activity at both the dose levels in normal, fasted rats. In alloxan induced diabetic rats, the body weight of the DA extract treated animals had shown a significant increase (P < 0.001) after 21 days treatment. The blood glucose level was reduced significantly by 47.48% and 52.09% after 21 days treatment at dose levels 100 and 200 mg/kg, respectively. Serum lipid levels, total protein, albumin, and creatinine were reversed toward near normal in treated rats as compared to diabetic control.Conclusion:The results indicate that ethanol extract of DA tubers possesses significant antidiabetic activity.

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Objective: The objective of this research is to identify the phytochemical constitutions present in Natural crude extract which obtained from Thumlappati district.Methods: Kidney stone is one of the most clinical disorder arising nowadays. They are existing due to the depletion of the urine and disproportionate execration of the components such as oxalate, phosphate, uric, cysteine, and struvite. Many alopathy medicine are not effectively curable in the case of kidney stone, consequently people are in need of traditional medicine system. Thus there is a great demand for research on potential inhibitor from natural products for dissolving kidney stone. In present work deals with an unknown crude extract collected from G. Thumlappati, Battalagundu Dindugal district Tamil Nadu. The crude extract of phytochemical are analyzed by using GCMS method.Results: Thus the sample has some bioactive compound to discharge the stone particles. So we subjected the crude extract sample to GC-MS process which reveals 210 compounds in 21 different peaks.Conclusion: This studies forms a basis for the biological characterization and importance of bioactive compounds were identified.