Polymorphism of CYP2E1 genotype is an important criterion for the development of hepatotoxicity before and during TB treatment while increased rifampicin level has no influence on it.
Intracerebroventricular injection of recombinant human interferon-2alpha (100-500 U/rat) decreased the mean effective dose of corasol inducing clonic convulsions in 50% kindled Wistar rats. This effect was more pronounced in delayed periods of kindling and was accompanied by enhancement of epileptiform signs on EEG.
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