Effects interferon-2α on seizures in corasol-induced kindling

Kresyun, V. I.; Kobolev, E. V.; Смірнов, І. В.; Godovan, V. V.; Godlevskii, L. S.

doi:10.1007/s10517-007-0240-6

Cited by 1 publication

(2 citation statements)

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“…As is known, the effect of LPS is manifested, in particular, in intensification of the release of cytokines [4]. It should be taken into account that the action of interferon 2-alpha (which significantly increases the seizure activity in the rat brain during the first 4 h from the moment of systemic administration of this agent in a dose of 1,000 IU/kg) is also associated with spectral modifications of EEG, namely an increase in the power of oscillations of the delta-and thetafrequency ranges accompanied by decreases in the powers of the alpha, beta, and theta activities [1,2,18]. At the same time, such a pattern of EEG changes indicates that the phenomenon of LPS-induced release of cytokines can only partially explain the facilitatory effect of LPS with respect to epileptiform activity.…”

Section: Lps-modified Eeg Activity In Ratsmentioning

confidence: 99%

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Effect of bacterial lypopolysaccharide on penicillin-induced seizure activity in rats

2008

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In experiments on Wistar rats, we found that, within an early period (2 to 4 h) after injection of bacterial lypopolysaccharide, LPS (0.1 mg/kg, i.p.), the latency of generalized seizures induced by injection of benzylpenicillin (sodium salt; 3.0 million IU/kg, i.p.) became significantly shorter, while the severity of seizure manifestations was higher than in the control group. Within this period, the power of oscillations of the delta and alpha-frequency ranges increased in the frontal cortex and hippocampal structures; fast ECoG components (beta and gamma rhythms) were suppressed, and the power of the theta activity decreased. In the hippocampal structures, these changes were more clearly pronounced, as compared with the neocortex. Within a later period of the action of LPS (12 to 18 h from the moment of injection), the latency of penicillin-induced seizures significantly exceeded the control value, and the severity of such seizures was lower. Under such conditions, we observed a smaller power of the synchronized activity of delta and alpha frequencies combined with intensification of the theta activity (most clearly pronounced in the hippocampal structures), and also an increase in the power of "desynchronized" rhythms (beta and gamma oscillations) in the cortex and hippocampus.

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Section: Lps-modified Eeg Activity In Ratsmentioning

confidence: 99%

“…These effects are manifested as intensification of kindling-induced epileptic activity; acute forms of convulsive disorders caused by systemic injections of epileptogens are also intensified [1][2][3].…”

Section: Introductionmentioning

confidence: 99%