Treatment with Cyproterone 200 mg/d induced no increase of total gonadotrophins in normal subjects. Plasma testosterone was elevated during the period of treatment. An alteration in the ratio LH/FSH has been suggested.
Urinary 17-KS showed no uniform pattern, but 17-KGS were always significantly elevated during Cyproterone treatment. Seminal fluid examinations showed no effect of Cyproterone (100 and 200 mg/d, total dose 4.2–38.6 g within 9 months) on spermatogenesis in 6 adults with normal gonadal function. No increase of spermatogenesis has been observed under treatment with Cyproterone (100 mg and 200 mg/d, total dose 3.5–35.4 g within 8 months) in 7 patients with oligospermia. Over a period of 21 days no influence of Cyproterone (200 mg/d) has been observed on the function of adrenal cortex, concerning cortisol- and aldosterone production, on the carbohydrate and lipid metabolism and on liver function in 5 subjects.
An acute renal failure was observed postoperatively in 3,45% of 929 patients operated with the heart lung machine during the years 1970-1972. Because of the bad results of any therapy in the case of acute postoperative renal failure, the diagnostic procedures of the preoperative renal function were intensified of the preoperative renal function were intensified in order to prevent an acute postoperative renal failure. Therefore additional measurements of the creatinine clearance and in few cases radioisotopic clearance tests were done.
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