Influence of an Antiandrogen (Cyproterone) on the Gonadotrophic Function of the Pituitary Gland, on the Gonads and on Metabolism in Normal Men

Rausch-Stroomann, J.-G.; Petry, R.; Hocevar, V.; Mauss, J; Senge, Th.

doi:10.1530/acta.0.0630595

Cited by 19 publications

(6 citation statements)

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“…However in 8 of these patients basal levels of LH at 4 weeks were similar to or lower than initial values and the transient increase at 2 weeks may therefore be of significance. Cyproterone, a steroidal antiandrogen, evoked increased basal levels of plasma testosterone when administered to volunteers (Rausch-Strooman et al 1970) and flutamide, a non-steroidal antiandrogen, also resulted in an increase in basal levels of testos¬ terone (Kliman et al 1974;Sizonenko et al 1974). …”

Section: Discussionmentioning

confidence: 99%

Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17β during treatment of duodenal ulcer in male patients

Peden

Boyd

Browning

et al. 1981

Acta Endocrinologica

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In a study of 51 male patients with duodenal ulcer, treatment with cimetidine was accompanied by an increase in basal levels of serum testosterone. Treatment with ranitidine, a new histamine H2-receptor antagonist, produced no such effect. It is concluded that cimetidine has antiandrogenic activity in man which is separate from the histamine H2-receptor blocking activity. Sexual dysfunction (Peden et al. 1979a; Wolfe 1979) and lowered sperm counts (Van Thiel et al. 1979) have been reported in man during treatment with cimetidine. Cimetidine has also been shown to exert antiandrogenic effects in animals (Leslie 8c Walker 1977; Winters et al. 1979) but ranitidine, a powerful new histamine H2-receptor antagonist apparently does not (Usadel 1979). We have there¬ fore compared the effects of these two drugs on basal levels of gonadotrophins, prolactin (Prl), tes¬ tosterone and oestradiol-17ß (Oe2) in male patients with duodenal ulcer (DU). Materials and Methods (a) PatientsThree groups were studied.(i) Thirty-three patients (mean age 39.5 years ± 4.5 SEM) with endoscopically proven duodenal ulcer were investigated. Twenty-two patients received cimetidine 1000 mg/day and were studied before and at the end of a 4 week course of treatment. The other 11 patients received cimetidine 800 mg/day in a subsequent double blind therapeutic trial of cimetidine against ranitidine (Peden et al., in press) and were studied before, after 2 weeks and at the end of their 4 week course of treatment.Twenty-eight of these patients achieved ulcer healing and 31 became asymptomatic.(ii) Eighteen patients (mean age 41.3 years ± 3.6 sem) received ranitidine and were studied before, after 2 weeks and at the end of a 4 week course of treatment. Six patients received a dosage of 320 mg/day in the double blind trial mentioned above, while 12 patients received 300 mg/day in a further open evaluation of a twice-daily dosage regime (Peden et al., in press). Sixteen of these patients achieved ulcer healing and all became asymp¬ tomatic.(iii) Nineteen patients who had been treated contin¬ uously with cimetidine 1000 mg/day and 2 patients

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Section: Discussionmentioning

confidence: 99%

Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17β during treatment of duodenal ulcer in male patients

Peden

Boyd

Browning

et al. 1981

Acta Endocrinologica

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“…The results of the present study indicate that low doses of CPA administered to adult male rhesus monkeys resulted in spermatogenic arrest, degeneration in epididymal morphology, alteration in polypeptide profile of spermatozoa, and the appearance of new polypeptides of possible lysosomal origin in epididymal fluid and cytosol. Cyproterone is tolerated well even at doses ranging from 100-200 mglday with no adverse effects on carbohydrate and lipid metabolism, adrenocortical, and liver functions (Rausch-Stroomann et al, 1970). Calcium and phosphate balance in men exposed to CPA were normal (Neumann and Schenk, 1975).…”

Section: 111mentioning

confidence: 99%

Effect of cyproterone acetate on structure and function of rhesus monkey reproductive organs

1992

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A low dose of Cyproterone acetate (CPA; 1 mg/kg body weight/day for 70 days) was administered to adult male rhesus monkeys to assess its effects on testicular and epididymal structure and function in a nonhuman primate species. CPA caused extensive degenerative changes in morphology of seminiferous, efferent duct, and epididymal epithelia, including decrease in diameter of seminiferous and epididymal tubules and their lumen, height of epididymal epithelium, and an increase in intertubular connective tissue. The protein profile of spermatozoa showed alterations during their epididymal transit in control and CPA-treated monkeys. In CPA-treated animals, 19 polypeptides were acquired and nine were eliminated during epididymal transit in contrast to acquisition of 12 and loss of 14 polypeptides in control animals. Treatment with CPA also resulted in the appearance of 14 new polypeptides in epididymal cytosol and luminal fluid, probably of lysosomal origin. The protein pattern of caput and cauda epididymal tubule cytosol, maintained in organ culture and exposed to 100 microM CPA for 3 days, showed absence of eight polypeptides. These results indicate that even at the low dose used in this study, CPA has caused spermatogenic arrest, degenerative changes in the epididymal structure, and alterations in epididymal and sperm protein profile. Suppression of serum testosterone levels indicates the need for androgen supplementation if CPA is to be used for male contraception.

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“…Cyproterone acetate has been used at doses ranging from 100-200 mg/day in normal men for over 9 months [24]; no effects were observed on seminal fluid, spermatogenic function, carbohydrate and lipid metabolism or func tion of the adrenal cortex. Since large doses of cyproterone acetate are clinically well tolerated by the human male, it is not unlikely that much smaller doses which may be needed for induction of functional sterility would be tolerated over extended periods of treatment.…”

Section: A New Approach To Control O F Fertility In the Malementioning

confidence: 99%

Action of Cyproterone Acetate on Male Reproductive Functions

Prasad¹,

Rajalakshmi²

1971

Gynecol Obstet Invest

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Influence of an Antiandrogen (Cyproterone) on the Gonadotrophic Function of the Pituitary Gland, on the Gonads and on Metabolism in Normal Men

Cited by 19 publications

References 0 publications

Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17β during treatment of duodenal ulcer in male patients

Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17β during treatment of duodenal ulcer in male patients

Effect of cyproterone acetate on structure and function of rhesus monkey reproductive organs

Action of Cyproterone Acetate on Male Reproductive Functions

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