The new system for collection and quantification of oral fluid helps to improve standardization of pre-analytics in oral fluid testing and to provide reliable and accurate quantification of analytes in oral fluid samples.
Land cover change processes are accelerating at the regional to global level. The remote sensing community has developed reliable and robust methods for wall-to-wall mapping of land cover changes; however, land cover changes often occur at rates below the mapping errors. In the current publication, we propose a cost-effective approach to complement wall-to-wall land cover change maps with a sampling approach, which is used for accuracy assessment and accurate estimation of areas undergoing land cover changes, including provision of confidence intervals. We propose a two-stage sampling approach in order to keep accuracy, efficiency, and effort of the estimations in balance. Stratification is applied in both stages in order to gain control over the sample size allocated to rare land cover change classes on the one hand and the cost constraints for very high resolution reference imagery on the other. Bootstrapping is used to complement the accuracy measures and the area estimates with confidence intervals. The area estimates and verification estimations rely on a high quality visual interpretation of the sampling units based on time series of satellite imagery. To demonstrate the cost-effective operational applicability of the approach we applied it for assessment of deforestation in an area characterized by frequent cloud cover and very low change rate in the Republic of Congo, which makes accurate deforestation monitoring particularly challenging.
The increasing availability of dense time series of earth observation data has incited a growing interest in time series analysis for vegetation monitoring and change detection. Vegetation monitoring algorithms need to deal with several time series characteristics such as seasonality, irregular sampling intervals, and signal artefacts. While common algorithms based on deterministic harmonic regression models account for intra-annual seasonality, inter-annual variations of the seasonal pattern related to shifts in vegetation phenology due to different temperature and rainfall are usually not accounted for. We propose a transition to stochastic modelling and present a near real-time change detection method that combines a structural time series model with the Kalman filter. The model continuously adapts to new observations and allows to better separate phenology-related deviations from vegetation anomalies or land cover changes. The method is tested in a forest change detection application aiming at the assessment of damages caused by storm events and insect calamities. Forest changes are detected based on the cumulative sum control chart (CUSUM) which is used to decide if new observations deviate from model-based forecasts. The performance is evaluated in two test sites, one in Malawi (dry tropical forest) and one in Austria (temperate deciduous, coniferous and mixed forests) based on Sentinel-2 time series. Both forest areas are characterized by a distinct, but temporally varying leaf-off season. The presented change detection method shows overall accuracies above 99%, users’ accuracies of 76.8% to 88.6%, and producers’ accuracies of 68.2% to 80.4% for the forest change stratum (minimum mapping unit: 0.1 ha). Results are based on visually interpreted points derived by stratified random sampling. A further analysis revealed that increasing the time series density by merging data from two Sentinel-2 orbits yields better forest change detection accuracies in comparison to using data from one orbit only. The resulting increase in users’ accuracy amounts to 7.6%. The presented method is capable of near real-time processing and could be used for a variety of automated forest monitoring applications.
Disorders of fibrinogen have been reported to be associated not only with bleeding and thrombosis but also with miscarriage. Here, we report the case of a woman with genetically determined hypofibrinogenemia and recurrent miscarriages who had a first successful pregnancy under fibrinogen substitution. Current knowledge on fibrinogen disorders and recurrent miscarriages is briefly summarized and discussed.
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