Hypofibrinogenemia and miscarriage: report of a first successful pregnancy under fibrinogen substitution and short review of the literature

Abstract

Disorders of fibrinogen have been reported to be associated not only with bleeding and thrombosis but also with miscarriage. Here, we report the case of a woman with genetically determined hypofibrinogenemia and recurrent miscarriages who had a first successful pregnancy under fibrinogen substitution. Current knowledge on fibrinogen disorders and recurrent miscarriages is briefly summarized and discussed.

The mechanism of Shoutai Wan in the treatment of recurrent spontaneous abortion - A review

“…Inadequate fibrin formation could result in ischemia, which hinders the proper implantation of the fertilized egg in the uterus, potentially leading to miscarriage [ 36 ]. Patients with coagulation abnormalities such as hemorrhagic defects, fibrinogen deficiency, and antiphospholipid syndrome are particularly susceptible to RSA [ 37 ]. Han et al [ 38 ] found that STW could effectively improve the prethrombotic state in patients with RSA, restoring balance in the anticoagulation-fibrinolysis system in uterine embryonic tissues.…”