We investigate planar periodically magnetized structures for use in targeting or controlling the delivery of therapeutic agents attached to small magnetic particles, and derive simple analytic expressions for the relevant magnetostatic forces. We show that improved particle trapping or confinement characteristics are possible relative to those that can be obtained with more conventional (i.e. uniformly magnetized) structures. These improvements include forces that are larger at close range (for equivalent magnetization densities) and that are both unidirectional and uniform over arbitrarily large areas parallel to the magnet surface. Expressions for the magnetostatic forces exerted on point-like magnetic particles in the vicinity of long rods (with circular and ellipsoidal cross sections) uniformly magnetized perpendicular to their axes are summarized in an appendix.
Magnetic nanoparticles possess many characteristics that make them promising as drug carriers and for use in biomedical applications. They can be attracted or magnetically guided by strong magnetic fields, thus acting as drug carriers. They can also be used for hyperthermia applications, due to the heat they produce in an alternating magnetic field. The resulting temperature increase can be used to modify or inhibit specific cell activities locally, or even to release drugs in a precisely controlled, temperature-increase activated manner. Magnetic nanoparticles can also serve as contrast agents for diagnostic applications such as magnetic resonance imaging.
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