Concomitant use of imatinib and rifampicin or other potent inducers of CYP4503A may result in subtherapeutic plasma concentrations of imatinib. In patients in whom rifampicin or other CYP3A inducers are prescribed, alternative therapeutic agents with less potential for enzyme induction should be selected.

15 V. 74) Sismmary. A total of 68 constituents, mainly aldehydes, ketones and esters, have been identifird for the first time in a black tea aroma concentrate using coupled gas-chromatography/ mass spectrometry. Introduction. -Tea is one of the world's most widely consumed beverages [l] 1) Two recent reviews by Sanderson &Graham [Z] and Sanderson [3] are a good introduction to the tea literature. For the most recent work on black tea aroma since the latest review [2], see [41 [51 FI.

Film-coated 100-mg (scored) and 400-mg tablet dose forms of imatinib are bioequivalent to the commercial 100-mg hard-gelatin capsule, and are as safe and well tolerated.

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Summary 2-Nitro-1,5-p-menthadiene (5), trans-and cis-6-nitro-1 (7), 2-p-menthadiene (6 and 7), trans-1 (7), 5-p-menthadien-2-yl acetate (9) and a formal phellandrene derivative, 7-isopropyl-5-methyl-5-bicyclo[2. Die Destillationsfraktion wurde mittels Adsorptions-Chromatographie an Aluminiumoxid von den Kohlenwasserstoffen befreit und die polaren Anteile an Kieselgel weiter aufgetrennt. Die unpolarste Zone (0,14% des 01s) wurde durch praparative Gas-Chromatographie in zwolf Fraktionen unterteilt. Die neuen Inhaltsstoffe (5-7, 9 und 16l)) wurden mit Hilfe von ein bis zwei gas-chromatographischen Operationen isoliert und anhand von 'H-NMR.-und Massenspektren charakteri- I)Die Formeln 5-7, 9 und 16 stehen im Zusammenhang mit den Verbindungen aus dem Angelica-01 fur eines der beiden Enantiomeren oder fur das Racemat.

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Peripheral vasospastic syndrome seems not to be a secondary response to insufficient resting energy expenditure. The results of the present study rather indicate an opposite tendency which deserves further investigation.