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Human myeloma cells freshly isolated from 40 patients with IgG multiple myeloma (MM, 10 in stage I and 30 in stage III), were cultured for 48 hours with recombinant B cell stimulatory factor 2 (rBSF-2)/interleukin- 6 (IL-6), which is considered a major growth factor for myeloma cells. Uptake of 3H-thymidine by these purified myeloma cells was measured, and BSF-2 response was evaluated by stimulation index and delta cpm induced by rBSF-2. Myeloma cells from cases in stage I responded to rBSF-2 better than those in stage III. Moreover rBSF-2 responders also showed better response to chemotherapy. Therefore, these results suggest that in vitro response of myeloma cells to BSF-2 correlates with disease progression and clinical response in patients of MM.

We attempted hydrophilization of a polyethylene terephthalate (PET) substrate surface with oxygen plasma to enhance the meniscus force, and the transfer yield of SOI islands to the PET substrate was improved to 99.97% (16 376/16 380s). In addition, we succeeded in the fabrication and operation of a floating-gate memory on a PET substrate below 130 °C. When the gate voltage was swept, clear clockwise hysteresis was observed. The memory window increased from ±0.1 V to ±1.7 V with an increasing sweep range of gate voltage from ±2 V to ±6 V. Also, we succeeded in the integration of single-crystalline silicon (c-Si) CMOS circuits and perovskite solar cell (PSC) modules. A c-Si CMOS ring oscillator was driven by the photovoltaics of a PSC module and the oscillation frequency was 8.9 MHz under illumination of 50 000 lx.

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