Pesticide measurement in foods is essential for human health. In recent years, multi-residue analysis has become the mainstream method for pesticides, but because the extraction method uses medium-polarity solvents, highly polar pesticides cannot be extracted using this method. Bipyridinium is a highly polar herbicide that is highly adsorbable. Its extraction therefore requires harsh conditions, such as a high concentration of a strong acid. The aim of this study is to investigate whether diquat and paraquat, typical bipyridinium herbicides, can be completely extracted under mild conditions by enzymatically solubilizing plant cell walls. Bipyridinium herbicides are difficult to measure by LC-MS/MS because of their highly cationic property. However, by using an ultra-weak cation exchange column, we were able to measure these herbicides with a separation and sensitivity that meet EU and Japan regulations.
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