Evaluation of the matrix effect on gas chromatography – mass spectrometry with carrier gas containing ethylene glycol as an analyte protectant

Fujiyoshi, Tomoharu; Ikami, Takahito; Sato, Takashi; Kikukawa, Koji; Kobayashi, Masato; Itô, Hiroshi; Yamamoto, Atsushi

doi:10.1016/j.chroma.2015.12.085

Cited by 38 publications

(16 citation statements)

References 32 publications

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“…In complex matrices, components within the matrix can affect the interaction between the analyte and the active sites of the column. 63 With continuous testing, this effect can be exacerbated because of the formation of new active sites by the accumulation of low-volatile matrix components. 63 After the SPE procedure, CAT was not identified in any of the samples, as evidenced in Figure 4d.…”

Section: Resultsmentioning

confidence: 99%

“…63 With continuous testing, this effect can be exacerbated because of the formation of new active sites by the accumulation of low-volatile matrix components. 63 After the SPE procedure, CAT was not identified in any of the samples, as evidenced in Figure 4d. If trace amounts of CAT were present on the flowthrough from the SPE, the concentration of these samples is very low and outside of the limit of detection of the instrument.…”

Section: Resultsmentioning

confidence: 99%

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Porous Cellulose Acetate/Block Copolymer Membranes for the Recovery of Polyphenolic Compounds from Aquatic Environments

et al. 2022

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Polyphenols are natural compounds with strong antioxidant properties synthesized by plants and widely distributed in plant tissues. They compose a broad class of compounds that are commonly employed for multiple applications such as food, pharmaceutical, adhesives, biomedical, agricultural, and industrial purposes. Runoffs from these sources result in the introduction of polyphenols into aquatic environments where they further transform into highly toxic pollutants that can negatively affect aquatic ecosystems and humans. Therefore, the development of extraction and remediation methods for such compounds must be addressed. This study describes the identification and operation of a method to recover polyphenolic compounds from water environments by utilizing membrane-based separation. Composite membranes derived from electrospun cellulose acetate (CA) fibers and diblock copolymer (DiBCP) PEO-b-P4VP were prepared to evaluate the adsorption of polyphenolic compounds from aqueous environments. The highly porous CA fibers were developed using the electrospinning technique, and the fabricated DiBCP/CA membranes were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FT-IR) spectroscopy, and tensile testing. Finally, the ability of the composite membranes to adsorb the soluble polyphenolic compounds catechol (CAT) and gallic acid (GA), from a wetland environment, was studied via batch adsorption experiments and by solid-phase extraction (SPE). Results revealed a successful recovery of both polyphenols, at concentrations within the parts per million (ppm) range, from the aqueous media. This suggests a novel approach to recover these compounds to prevent their transformation into toxic pollutants upon entrance to water environments.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Porous Cellulose Acetate/Block Copolymer Membranes for the Recovery of Polyphenolic Compounds from Aquatic Environments

et al. 2022

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“…The optimized method is reliable for the simultaneous detection of 43 pesticide residues in Schizonepeta tenuifolia . On the other hand, regarding the problem of the low recovery rate of Chlorothalonil, Thiamethoxam, and Dicofol, with no obvious experimental evidences obtained to explain the phenomenon, some instrumental condition variations, analytical error, decomposition of target in blank extract, and any other mechanisms were believed to be linked [ 27 , 28 ]. The other ways should be investigated to improve the recovery of them in our future work.…”

Section: Resultsmentioning

confidence: 99%

Rapid Simultaneous Determination of 43 Pesticide Residues in Schizonepeta tenuifolia by Gas Chromatography Mass Spectrometry

Zhou

Liu

et al. 2021

International Journal of Analytical Chemistry

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A simple, fast, and reliable method was established for simultaneous determination of 43 pesticides in Schizonepeta tenuifolia. The samples were prepared using solid-phase extraction (SPE) method. Pesticides were extracted from Schizonepeta tenuifolia using acetonitrile, cleaned with Pesticarb/NH2, and eluted by mixed solvents of acetonitrile and toluene (3 : 1, v/v). Selected pesticides were identified using DB-35MS capillary column and detected by gas chromatography mass spectrometry. Samples were quantified by external standard method. Recoveries for the majority of pesticides at spike levels of 0.2, 0.5, and 1 mg kg−1 ranged between 70 and 120% (except for Chlorothalonil, Thiamethoxam, and Dicofol), and the relative standard deviations (RSDs n = 6) were 1.32%–13.91%. Limits of detection (LODs) were 0.0011–0.0135 mg kg−1, whereas limits of quantification (LOQs) were 0.0038–0.0451 mg kg−1. The satisfactory accuracy and precision, in combination with a good separation and few interferences, have demonstrated the strong potential of this technique for its application in Schizonepeta tenuifolia analysis.

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“…Additional information, such as clustering of fragments across multiple samples can be used to identify highly correlated fragments based on peak intensities. Matrix effects in GC (Fujiyoshi et al, 2016;Sakthiselvi et al, 2020) are important for determining the extent of background noise. These matrix effects will depend on sample type, concentration, preparation, and introduction, as well as the chromatography and acquisition strategies employed.…”

Section: Peak Filtering To Remove Background Contaminants and Artifactsmentioning

confidence: 99%

An Actionable Annotation Scoring Framework for Gas Chromatography - High Resolution Mass Spectrometry (GCHRMS)

Koelmel

Xie

Price

et al. 2022

Preprint

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Omics-based technologies have enabled comprehensive characterization of our exposure to environmental chemicals (exposome) as well as assessment of the corresponding biological responses at the molecular level (e.g., metabolome, lipidome, proteome, and genome). By systematically measuring personal exposures and linking these stimuli to biological perturbations, researchers can determine specific chemical exposures of concern, identify mechanisms and biomarkers of toxicity, and design interventions to reduce exposures. However, further advancement of metabolomics and exposomics approaches is limited by a lack of standardization and approaches for assigning confidence to chemical annotations. While a wealth of chemical data is generated by gas chromatography high-resolution mass spectrometry (GC-HRMS), incorporating GC-HRMS data into an annotation framework, and communicating confidence in these assignments is challenging. It is essential to be able to compare chemical data for exposomics studies across platforms to build upon prior knowledge and advance the technology. Here we discuss the major pieces of evidence provided by common GC-HRMS workflows, including retention time and retention index, electron ionization, positive chemical ionization, electron capture negative ionization, and atmospheric pressure chemical ionization spectral matching, molecular ion, accurate mass, isotopic patterns, database occurrence, and occurrence in blanks. We then provide a qualitative framework for incorporating these various lines of evidence for communicating confidence in GC-HRMS data by adapting the Schymanski scoring schema developed for reporting confidence levels by liquid chromatography high-resolution mass spectrometry (LC-HRMS). Validation of our framework is presented using standards spiked in plasma, and confident annotations in outdoor and indoor air samples, showing a false positive rate of 12% for suspect screening for chemical identifications assigned as Level 2 (when structurally similar isomers are not considered false positives). This framework is easily adaptable to various workflows and provides a concise means to communicate confidence in annotations. Further validation, refinements, and adoption of this framework will ideally lead to harmonization across the field, helping to improve the quality and interpretability of compound annotations obtained in GC-HRMS.

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Evaluation of the matrix effect on gas chromatography – mass spectrometry with carrier gas containing ethylene glycol as an analyte protectant

Cited by 38 publications

References 32 publications

Porous Cellulose Acetate/Block Copolymer Membranes for the Recovery of Polyphenolic Compounds from Aquatic Environments

Porous Cellulose Acetate/Block Copolymer Membranes for the Recovery of Polyphenolic Compounds from Aquatic Environments

Rapid Simultaneous Determination of 43 Pesticide Residues in Schizonepeta tenuifolia by Gas Chromatography Mass Spectrometry

An Actionable Annotation Scoring Framework for Gas Chromatography - High Resolution Mass Spectrometry (GCHRMS)

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