Although the technology is still in its early stages, presented models are considered useful in preoperative planning and patient and student education. There are multiple factors limiting the use of 3D printing in everyday healthcare, the most important being high costs and the time-consuming process of development. Promising early results need to be verified in larger randomized trials, which will provide more statistically significant results.
Anti-vaccination movement has existed as long as the vaccines themselves, but its mode of action and social influences evolved over time. Such attitude with no doubt has negative impact on vaccination rates and eradication of infectious diseases. In this study, we used an online survey to examine vaccination attitudes of Polish university students of various degree and specialties. A total of 1,386 questionnaires were completed, among them 617 from students attending medical schools and 769 from students of non-medical schools. Up to 95.24% (N = 1320) of the study subjects, among them 98.70% and 92.46% of students of medical and non-medical specialties, respectively, declared willingness to vaccinate their children. 47.19% (N = 654) of participants have a contact with anti-vaccination propaganda at least once in a lifetimes. 42.64% (N = 591) of respondents were aware of the existence of anti-vaccination movements; 45.35% (N = 414) of participants, including 306 (51.52%) and 108 (33.86%) students of medical and non-medical disciplines, respectively, considered such movements as a negative phenomenon. Vaccination attitudes of students from medical and non-medical universities differed considerably. Vaccination knowledge and awareness among the students from non-medical universities were rather poor, markedly lower than in the students of medical disciplines. Nevertheless, irrespective of their major, Polish students have considerable knowledge gaps with regards to vaccination and need additional education in this matter.
PurposeAlthough high costs are often cited as the main limitation of 3D printing (3DP) in the medical field, current lack of clinical evidence is asserting itself as an impost as the field begins to mature. The aim is to review clinical trials in the field of 3DP, an area of research which has grown dramatically in recent years.MethodsWe surveyed clinical trials registered in 15 primary registries worldwide, including ClinicalTrials.gov. All trials which utilized 3DP in a clinical setting were included in this review. Our search was performed on December 15, 2017. Data regarding the purpose of the study, inclusion criteria, number of patients enrolled, primary outcomes, centers, start and estimated completion dates were extracted.ResultsA total of 92 clinical trials with 252 patients matched the criteria and were included in the study. A total of 42 (45.65%) studies cited China as their location. Only 10 trials were multicenter and 2 were registered as international. The discipline that most commonly utilized 3DP was Orthopedic Surgery, with 25 (27.17%) registered trials. At the time of data extraction, 17 (18.48%) clinical trials were complete.ConclusionsAfter several years of case reports, feasibility studies and technical reports in the field, larger-scale studies are beginning to emerge. There are almost no international register entries. Although there are new emerging areas of study in disciplines that may benefit from 3DP, it is likely to remain limited to very specific applications.Electronic supplementary materialThe online version of this article (10.1007/s11548-018-1793-8) contains supplementary material, which is available to authorized users.
Surgical treatment is the most important part of therapy for endometrial cancer. The aim of the study was to define factors having the most significant impact on surgical treatment of endometrial cancer when using traditional and laparoscopic methods. In the study, we evaluated 75 females who were treated for endometrial cancer via laparoscopic surgery in 2019 and used a historical control of 70 patients treated by laparotomy in 2011. The evaluated risk factors included the method of surgery, type of lymphadenectomy, patient’s age, various obesity parameters, histological grading, cancer clinical staging, pelvic dimensions, previous abdominal surgeries, comorbidities, and number of deliveries. The duration of hospitalization, operation time, loss of hemoglobin, and procedure-related complications were used as parameters of perioperative outcomes. Multivariable linear regression analysis confirmed the following factors as being predictors of worse perioperative outcomes: laparotomy, abdominal obesity (waist circumstance and waist-to-hip ratio), range of lymphadenectomy, prior abdominal surgeries, and larger pelvic dimensions. Abdominal obesity is a significant risk factor in the treatment of endometrial cancer. Laparotomy continues to be utilized frequently in the management of endometrial cancer in Poland as well as elsewhere, and adopting a minimally invasive approach is likely to be beneficial for patient outcome.
Introduction: On account of its radical character, suicide is differently perceived by the society. The consequence of this phenomenon is the issue of moral evaluation by the society in the practical aspects of daily life, such as religious, psychological and social ones. Regarding society's complexity, it is understandable that the knowledge and the evaluation of this act amongst people are different.Materials and methods: In the study a method of the diagnostic survey was applied. The questionnaire was conducted amongst 168 individuals ranging from 18 to 49 years of age. The study involved 69 women and 99 men. The arranged personal data questionnaire served as the evaluation of perceiving the suicidal act and people's knowledge about this occurrence.Results: Respondents claim that suicidal behaviours affect 72.5% of young people, and 22.7% of adult men. Large group of the study participants had personal experience with individuals after a suicide attempt (41.92%). As many as 49.7% of individuals are fierce opponents of suicidal acts while 46.1% are of an opinion that 'the one who commits suicide should not be condemned or judged'.Conclusions: Respondents present vast knowledge about the universality of suicide phenomenon and its most frequent causes. They are against such behaviour, but do not condemn individuals who committed this act. The study participants show understanding of ways to prevent suicide.
Introduction. The problem of health care affects every country. The structure and quality of hospitalization in Poland have changed over recent years. The state’s management of a balanced policy is possible prior to the collection of reports allowing to obtain data enabling assessment of changes in the health structure of the population, development of statistical data, as well as implementation and supervision of the National Health Program. Aim. The aim of the study was to evaluate the quality of hospitalization basing on the patients’ assessment of the availability, conditions, course of treatment and contact with hospital staff in the city of Lublin. Material and methods. The material for analysis was data collected from 254 patients. Respondents represented departments of diabetology, rehabilitation and internal diseases. The group consisted of 159 women and 95 men aged 19-84. The interview questionnaire was a research tool. Respondents were asked to assess: accessibility to hospital, efficiency of completing formalities when admitted to the hospital, cleanliness in the room, quality of the gastronomic services and contact with nursing and medical staff. Likert’s 5-point scale was used. Statistical analysis was performed using the software “STATISTICA 10.0”. Results. Most respondents assessed the quality of hospitalization as satisfactory. As many as 99% of respondents assessed contact with doctors as good or very good. Contact with nursing staff was rated as good by 88% of respondents. Conclusions. This study demonstrated good quality of health care in the examined hospital in Lublin. However, it is important to emphasize the need for further research aimed at collecting data on the presented problem.
Introduction. Aflatoxins are metabolites produced by Aspergillus flavus and Aspergillus parasiticus. Due to the high prevalence of aflatoxin-containing products they are common issue of the observational studies. Observational studies have demonstrated the hepatotoxic effects of aflatoxins in humans. However, the exact pathogenetic mechanisms of the effect of aflatoxin B1 on the above-mentioned hepatotoxicity have not yet been known. Aim of the study. The aim of the study was to assess the toxic effects of different doses of aflatoxin B1. The analyze was performed using assessment of concentration of NF-κB in liver tissue homogenates after a 7-day intoxication with this mycotoxin. Material and methods. The studies were carried out on Wistar male rats which were selected randomly, according to the principle of simultaneity for the control group and the study groups. The concentration of NK-κB was determined by immunoenzymatic ELISA in the obtained supernatants of liver taken from decapitated animals. The statistical analysis was performed with Statistica 13.3 (Statsoft, USA). Results. The statistical significance of the difference between the concentrations in the control and study group receiving 1.0 mg/kg of aflatoxin B1 and between the control and study group who received aflatoxin B1 at a dose of 2.0 mg/kg body weight (p <0,05) were demonstrated. A significant relationship was also found between the level of dose of aflatoxin B1 administered to the rats and the concentration of NF-κB. Negative correlations were obtained. The higher dose administered to rats - the lower level of measured concentration of NF-κB. Conclusions. The study of the influence of aflatoxin B1 on the level of NF-κB transcription factor may significantly contribute to understand the mechanism of its action, influence on inflammatory, apoptotic and carcinogenic processes in the liver and determine its safe level in food intended for humans and animals.
palliative treatment applies to people already burdened with surgery, chemotherapy, or simply their advanced age and the accompanying diseases. Regarding author's clinical experience, it is often the case that terminally ill patients have a significantly lowered seizure threshold, unstable glycemic level, high or low blood pressure. In fact, these may be the consequences of numerous other drugs, organic brain damage, and often metastatic tumors. This fact should also be taken into account when determining the standard of pharmacotherapy. The use of individual pharmacological agents is, however, primarily determined by the clinical condition of the patient, the simultaneous administration of other pharmaceuticals, or simply the clinical sense and experience of the physician. There is no one or rigidly specified procedure. There are situations when patients are simply unable to receive the medicine orally, in which case the main criterion becomes a form that allows intravenous or intramuscular administration, and not the most appropriate clinical profile. It should be remembered that among medicines used in psychiatry not always a form other than oral is obvious.
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