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Innate inflammatory responses are crucial for induction and regulation of T cell and antibody responses. Mast cell (MC)-deficient Kit mutant mice showed impaired adaptive immunity, suggesting that MCs provide essential adjuvant activities, and pharmacological MC activation was proposed as a new adjuvant principle. However, the Kit mutations result in complex alterations of the immune system in addition to MC deficiency. We revisited the role of MCs in vaccination responses using Mcpt5-Cre R26DTA/DTA and Cpa3Cre/+ mice that lack connective tissue MCs or all MCs, respectively, but feature an otherwise normal immune system. These animals showed no impairment of T and B cell responses to intradermal vaccination with protein antigen plus complete Freund’s adjuvant. Moreover, we demonstrate that the adjuvant effects of the MC secretagogue c48/80 in intradermal or mucosal immunization are independent of the presence of MCs. We hence find no evidence for a regulation by MCs of adaptive immune responses to protein antigens. The finding that immunological MC functions differ from those suggested by experiments in Kit mutants, emphasizes the importance of rigorous tests in Kit-independent MC-deficiency models.

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Currently, demand response resources can sell load reductions in wholesale energy markets. However, paying for load reductions ultimately results in an unbalanced market, where the amount of resources sold (megawatts) is less than the amount of resources bought (megawatts and "negawatts"). To resolve this imbalance, the ISO must allocate the cost of compensating demand response to those buyers who benefit from reduced LMPs. Current cost allocation methods are quite broad and based on each energy buyer's share of the total load. In an uncongested network, this results in a "fair" allocation of costs, i.e., an allocation proportional to the benefits that each party accrues. However, in a congested network, this is no longer the case, as price separation occurs between nodes. In this paper, we therefore propose a cost allocation method based on LMP sensitivity that accounts for the effect of congestion on the distribution of benefits between nodes with different LMPs. Since this sensitivity-based method only takes into account the cost allocation per node, we also propose a means of allocating costs between individual load serving entities (LSEs) at a single node. Due to this refinement, LSEs are rewarded according to their individual contribution to demand response. Finally, we define a fairness index to evaluate the performance of the proposed method as compared to a load-based allocation. We find that when load reductions are small (1%-3% total load), the fairness index of the proposed method is very close to zero, indicating almost identical benefit to cost ratios for all market participants. Although the fairness index increases with increasing load reductions, results show that even for larger load reductions, the fairness index is still lower for the proposed method than for the load-based allocation method.Index Terms-Cost allocation, demand response, wholesale energy markets.