Aim: To test the sensitivity of S. Enteritidis for selected antibiotics. Materials and Methods: S. Enteritidis isolates obtained from different samples of chicken, mutton, turkey meat, faecal and cloacal samples of poultry and turkey, eggs, water and feed were subjected for sensitivity and resistance to selected antibiotics like- Chloramphenicol (30μg), Gentamicin (10 μg), Nalidixic Acid (30 μg), Tetracycline (30 μg), Ciprofloxacin (5 μg), Amikacin (30 μg), Amoxicillin (25 μg), Ampicillin (10 μg), Streptomycin (10 μg) and Sulfonamide (30 μg). Antimicrobial susceptibility of the isolates was established by the disk diffusion assay with MH (Muller-Hinton) agar in accordance with French National Antibiogram Committee Guidelines. Results: The sensitivity of S. Enteritidis was 100% for ciprofloxacin followed by chloramphenicol and amikacin (96%), gentamycin (90%), amoxicillin (82%), streptomycin (80%), tetracycline (76%), nalidixic acid (68%), ampicillin (58%) and sulfonamide (10%). The resistance was highest for sulfonamide (76%) followed by ampicillin (32%), nalidixic acid (30%) and 6-20% for gentamycin, amoxicillin and tetracycline. Conclusion: S. Enteritidis isolates were more sensitive to ciprofloxacin, chloramphenicol, amikacin, gentamycin, streptomycin,amoxicillin and tetracyclines and less sensitive to sulfonamides. Higher resistance was observed with sulfonamide followed by ampicillin and nalidixic acid. [Vet World 2013; 6(4.000): 185-188