Vestibular migraine (VM) is one of the most debilitating chronic diseases that is currently underdiagnosed and undertreated. The treatment of VM is a dynamic and rapidly advancing area of research. New developments in this field have the potential to improve the diagnosis and provide more individualized treatments for this condition. In this review, we discussed the progress of evidence-based treatment of VM, including pharmacotherapy and nonmedical methods. A search of the literature was conducted up to September 2019. In order to control or cure VM, patients should follow three steps. First, patients should comply with diet and behavioral medication; Second, during the attack of VM, patients should take medicine to control the symptoms. These acute attack treatment of VM consists of antiemetic medications (e.g., dimenhydrinate and benzodiazepines), anti-vertigo medicine, and analgesics (e.g. triptans). Third, prophylactic medicine (e.g., propranolol, topiramate, valproic aid, lamotrigine, and flunarizine) can be used to reduce the frequency and severity of VM attack. Also, vestibular rehabilitation (VR) treatment should be considered for all VM. Meanwhile, we also propose to establish a culture of prevention which is essential for reducing the personal, social and economic burden of VM.
Based on the special rheological model of foam fluid, the mathematical models of cuttings transport for stable foam drilling in vertical/near vertical sections, the transitional section, and inclined/horizontal sections are established in this paper. The effects of various flow parameters on the cuttings bed thickness in the annulus are analyzed. The results show that inclination, annulus velocity, foam flow rate, and eccentricity are key factors affecting cuttings transport. The thickness of a cuttings bed gradually decreases with the inclination decrease of the highly deviated/horizontal sections. When the inclination is reduced to approximately 60°, the dynamic and static cuttings bed disappears and is substituted by the glide lamella, which consists of cuttings grains. Cuttings grains have various forms of movement on the lower borehole wall. When the inclination is reduced to below 30°, the cuttings are brought out of the well by the stable foam if the returning velocity of the annulus foam is larger than the depositing velocity of the cuttings. The thickness of the cuttings bed gradually decreases with the increase of annulus velocity. The increased foam quality reduces the concentration of annulus cuttings when the annulus velocity is constant and when it reaches a stable status earlier than the foam drilling fluid of lower foam quality. However, the concentration of the annulus cuttings at the final stage is constant. The thickness of the cuttings bed increases with increased eccentricity of the drill stem. When the eccentricity is large, the change of eccentricity has a high effect on the cuttings bed thickness.
With the rapid development of economic globalization, more and more enterprises focus their development planning on the brand strategy. An excellent brand strategy should be supported by good design management, and a successful brand strategy comes from high-level design management. In this paper, the status quo of design management and the role of brand strategy are introduced. “MUJI” is taken as an example to illustrate that design management runs through the brand strategy and the importance of design management to brand strategy.
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