Implant-related infections are a serious complication in prosthetic surgery, substantially jeopardizing implant fixation. As porous coatings for improved osseointegration typically present an increased surface roughness, their resulting large surface area (sometimes increasing with over 700% compared to an ideal plane) renders the implant extremely susceptible to bacterial colonization and subsequent biofilm formation. Therefore, there is particular interest in orthopaedic implantology to engineer surfaces that combine both the ability to improve osseointegration and at the same time reduce the infection risk. As part of this orthopaedic coating development, the interest of in vitro studies on the interaction between implant surfaces and bacteria/biofilms is growing. In this study, the in vitro staphylococcal adhesion and biofilm formation on newly developed porous pure Ti coatings with 50% porosity and pore sizes up to 50 μm is compared to various dense and porous Ti or Ti-6Al-4V reference surfaces. Multiple linear regression analysis indicates that surface roughness and hydrophobicity are the main determinants for bacterial adherence. Accordingly, the novel coatings display a significant reduction of up to five times less bacterial surface colonization when compared to a commercial state-of-the-art vacuum plasma sprayed coating. However, the results also show that a further expansion of the porosity with over 15% and/or the pore size up to 150 μm is correlated to a significant increase in the roughness parameters resulting in an ascent of bacterial attachment. Chemically modifying the Ti surface in order to improve its hydrophilicity, while preserving the average roughness, is found to strongly decrease bacteria quantities, indicating the importance of surface functionalization to reduce the infection risk of porous coatings.
In the biomedical field, modification of titanium surfaces to improve the osteoinductive and antibacterial behavior is widely investigated. This functionalization can be further ameliorated by providing a porous coating with high loading capacity for bioactive materials and drug delivery carriers at the implant surface. In this work, a new powder metallurgical processing route used to deposit such porous pure titanium coatings on Ti based substrates is presented. The coatings were prepared by electrophoretic deposition (EPD) of TiH2 powder suspensions followed by dehydrogenation and sintering in vacuum. The use of hydrides allowed to lower the sintering temperature below that of the α–β transition of the Ti6Al4V substrate. Measurement of the tensile bond strength confirmed a strong adhesion of the porous coating. Deposition of powders with different grain sizes resulted in porous titanium coatings with varying thickness, pore morphology, and surface roughness. The possibility to extend this coating technique to complex shaped implants is highlighted.
Porous titanium coatings on dense Ti6Al4V substrates were made by electrophoretic deposition (EPD) of titanium particle stabilized Pickering emulsions. The samples were consecutively dried and microwave sintered in helium to prevent oxidation. The obtained coatings have a thickness ranging from 50 to 250 μm with open spherical macropores in the 20 to 200 μm range.
Bulk titanium foams were prepared by emulsion templating during slip casting. The emulsion template was stabilized using partially hydrophobized titanium particles while the continuous phase consisted of a titanium hydride powder suspension. Sintering was performed in inert atmosphere. The use of titanium hydride resulted in lower sintering temperatures and denser, stronger struts. Both homogeneous foams with high compressive strength and structures with a gradient in pore size were obtained.
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