Cs WO nanorods coated with polyelectrolyte multilayers are developed as "four-in-one" multifunctional nanomaterials with significant potential for computed tomography/photoacoustic tomography bimodal imaging-guided photothermal/photodynamic cancer treatment.
Over the past years the performance of electrochromic smart windows with the promising potential for significant energy savings has been progressively improved; however, the electrochromic windows have not yet to come into use at scale mainly because the electrochromic materials suffer from some significant drawbacks such as low coloration efficiency, slow switching time, bad durability and poor functionality. Herein, we fabricate the optically modulated electrochromic smart devices through sequential deposition of the crown-type polyoxometalates, KLiHPWO·92HO (PW), and WO nanowires. Unlike most reported electrochromic smart devices, the resulting PW and WO nanocomposites allow active and selective manipulation of the transmittance of near-infrared (750-1360 nm) and visible light (400-750 nm) by varying the applied potential. Furthermore, thanks to the stable nature of both PW and WO and precise structural control over the nanocomposites, the prepared electrochromic smart devices exhibit high efficiency, quick response and excellent stability.
Similar to translated thermal ablative techniques in clinic, the occurrence of cellular necrosis during tumor photothermal therapy (PTT) would induce inflammatory responses that are detrimental to therapeutic outcomes. Inspired by the well-known colorimetric Folin−Ciocalteu assay, monodispersed and renal-clearable tungsten (W)-based polyoxometalate nanoclusters (W-POM NCs, average diameter of around 2.0 nm) were successfully obtained here through a facile redox reaction with natural gallic acid in alkaline aqueous solution. Apart from excellent stability in the form of freezedried powder, the as-prepared W-POM NCs occupied considerable biocompatibility toward normal cells/tissues both in vitro and in vivo, since no obvious toxicities were observed by treating female Balb/c mice with concentrated W-POM NCs during the 30 day post-treatment period. More importantly, W-POM NCs exhibited not only considerable nearinfrared (NIR) light absorption (coloration effect originated from the existence of electron-trapped W 5+ ) for efficient PTT but also impressive anti-inflammatory ability (eliminating inflammation-related reactive oxygen species by the oxidation of W 5+ into W 6+ state) to achieve better therapeutic outcomes. Thus, our study pioneers the application of POMs for noninflammatory PTT with expected safety and efficiency.
An inactive organoplatinum(IV)-substituted polyoxometalate is developed as an efficient and nontoxic prodrug with significant potential for treating human colorectal cancers. Further encapsulation of Pt(IV) -PW11 with DSPE-PEG2000 nanoparticles (NPs) enables targeted delivery and controlled release of inactive prodrug. Such Pt(IV) -PW11 -DSPE-PEG2000 NPs are highly efficient in inhibiting cellular growth of HT29 cells and treating human colorectal cancer in mice, superior to classic cisplatin.
(K,Na)NbO3 (KNN) particles were successfully prepared by hydrothermal synthesis. The results showed that Na+ reacted more readily with Nb to form NaNbO3 than K+. For the purpose of obtaining KNN particles with K/Na=1, a mixed alkaline solution with K+/Na+ ratios ranging from 3.5/1 to 4/1 was required as a starting solution. The morphology and size of KNN particles synthesized strongly depended on K/Na ratio in the KNN particles. The KNN particles synthesized from the starting alkaline solution with K+/Na+=3.5/1 were the smallest with a pelletlike morphology affected by NaNbO3- and KNbO3-based particles. Surfactants such as sodium dodecylbenzenesulfonate (SDBS) and sodium hexametaphosphate (SH) were used to synthesize well dispersed and small KNN particles. Platelike KNN particles with 100 nm thickness and 1.5 µm width were obtained in this study.
Aggregated b-amyloid (Ab)iswidely considered as akey factor in triggering progressive loss of neuronal function in Alzheimersd isease (AD), so targeting and inhibiting Ab aggregation has been broadly recognized as an efficient therapeutic strategy for curing AD.H erein, we designed and prepared an organic platinum-substituted polyoxometalate, (Me 4 N) 3 [PW 11 O 40 (SiC 3 H 6 NH 2 ) 2 PtCl 2 ]( abbreviated as Pt II -PW 11 )f or inhibiting Ab 42 aggregation. The mechanism of inhibition on Ab 42 aggregation by Pt II -PW 11 was attributed to the multiple interactions of Pt II -PW 11 with Ab 42 including coordination interaction of Pt 2+ in Pt II -PW 11 with amino group in Ab 42 ,electrostatic attraction, hydrogen bonding and van der Waals force.I nc ell-based assay, Pt II -PW 11 displayed remarkable neuroprotective effect for Ab 42 aggregation-induced cytotoxicity,l eading to increase of cell viability from 49 %t o 67 %a tadosage of 8 mm.M ore importantly,t he Pt II -PW 11 greatly reduced Ab deposition and rescued memory loss in APP/PS1 transgenic AD model mice without noticeable cytotoxicity,d emonstrating its potential as drugs for AD treatment.
We demonstrate a versatile nanoparticle with imaging-guided chemo−photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property,
Electrodynamic therapy (EDT) and chemodynamic therapy (CDT) have the potential for future tumor treatment; however, their underlying applications are greatly hindered owing to their inherent drawbacks. The combination of EDT and CDT has been considered to be an effective way to maximize the superiorities of these two ROS-based methodologies. However, the development of novel nanomaterials with "one-for-all" functions still remains a big challenge. In this work, the polyoxometalate nanoparticles (NPs) were decorated using the zeolite imidazole
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